Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B. Pharmacy III Medicinal Chemistry-II Previous Question Paper (March - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
Define antimetabolites. Give the structure of Azathioprine.
Answer
Antimetabolites are structural analogs of normal metabolites that interfere with the synthesis of essential cellular components, such as DNA or RNA, by competing with natural substrates for enzymes or by being incorporated into nucleic acids, thereby inhibiting cell growth and division. They are primarily used as antineoplastic or immunosuppressive agents.
The structure of Azathioprine is 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-9H-purine.
Write a note on synthesis of Promethazine hydrochloride.
Answer
Promethazine hydrochloride is synthesized starting from phenothiazine. The process involves the following steps:
- Phenothiazine is reacted with 2-chloropropyl dimethylamine in the presence of a strong base like sodium amide (NaNH2) in a non-polar solvent such as xylene or toluene.
- This reaction involves the N-alkylation of the phenothiazine nitrogen atom with the side chain.
- The resulting base, promethazine, is then treated with hydrochloric acid in an organic solvent like ether or ethanol to form the stable, crystalline promethazine hydrochloride salt.
Give the structure and uses of spironolactone.
Answer
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Write a note on synthesis and uses of nitroglycerine.
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Give the structure and uses of sotalol and Mexiletine hydrochloride.
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Describe the mechanism of action of Lovastatin.
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Write the structure and uses of Diethyl stilbestrol.
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Discuss in detail the metabolism of steroids.
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Write the structure and uses of Etidocaine.
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Write a note on Meglitinides. Give the structure and uses of Nateglinide.
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PART - B
Define and classify antihistaminic agents with suitable examples and explain the synthesis and mechanism of action of diphenhydramine HCl.
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Write the mechanism of action, synthesis and uses of Triprolidine hydrochloride
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Outline the structure, uses and mechanism of action of Etoposide, Vinblastin sulphate, Vincristin sulphate.
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Write a note on Carbonic anhydrase inhibitors. Explain the synthesis and mechanism of action of Acetazolamide.
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Define antihypertensive agents? Explain the MOA of angiotensin receptor blockers. Write the synthesis of Methyldopate hydrochloride.
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Write the structure, mechanism of action and uses of Amiodarone and Quinidine sulphate.
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Write the structure, mechanism of action and uses of Anisindione and clopidogrel.
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Describe the synthesis, mechanism of action and uses of Disopyramide phosphate.
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Discuss the structure, mechanism of action and uses of Tezosentan.
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Write a note on endocrine system. Give the nomenclature of steroids and write the structure and mechanism of action of Nandralone.
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Write a note on corticosteroids. Discuss the structure, mechanism of action, uses of Hydrocortisone and Prednisolone.
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Give the structure, uses and mechanism of action of Mifepristone and Norgestril.
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Write a note on anti-thyroid drugs. Give the structure, mechanism of action and uses of Propylthiouracil and Methimazole.
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Define and Classify Local anesthetics with suitable examples and write the SAR of lidocaine derivatives.
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Write a note on Lidocaine/Anilide derivatives. Give the structure, mechanism of action and uses of Mepivacaine and Etidocaine.
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Discuss the synthesis, mechanism of action and uses of Dibucaine.
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