JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy III Year PHARMACOLOGY - I Previous Question Paper (December-2019 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Define an agonist and give examples.
Answer
An agonist is a drug that binds to a specific receptor and activates it to produce a biological response, mimicking the action of endogenous substances. Examples include Adrenaline (acting on adrenergic receptors) and Morphine (acting on opioid receptors).
Explain Tachyphylaxis.
Answer
Tachyphylaxis is the rapid development of tolerance to the effects of a drug following repeated administration over a short period. It occurs due to mechanisms such as receptor desensitization, depletion of endogenous mediators, or physiological adaptation. A classic example is the diminished pressor response to repeated doses of ephedrine.
What are pharmacokinetic drug interaction? Give examples.
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Explain Dose- Response relationship.
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Outline the synthesis of Nor-adrenaline.
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List the drugs used in Glaucoma. Add a line on their mechanism of action.
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Explain the role of Serotonin in CNS.
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Explain the role of Dopamine in CNS.
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Explain any two Nootropics.
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Explain any two CNS stimulant drugs.
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Part B - Unit I
Write the merits and demerits of oral route of administration. Discuss the enzyme inhibition and its significance.
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Explain passive diffusion. Discuss the factors influencing drug absorption.
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Part B - Unit II
Illustrate the signal transduction through G-Protein coupled receptors.
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Explain factors modifying drug action.
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Part B - Unit III
Classify Parasympathomimetics with suitable examples. Write the pharmacology of Acetylcholine.
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Classify Local anesthetics with suitable examples. Write their mechanism of action.
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Classify Neuromuscular blocking agents. Write about D- tubocurarine.
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Part B - Unit IV
Classify Anti-epileptics. Write mechanism of action, uses and adverse effects of Phenytoin.
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Write the pharmacology of Benzodiazepines.
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Part B - Unit V
Classify Anti- parkinsonian drugs with suitable examples. Write the pharmacological actions and adverse effects of L- Dopa.
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Write a note on:
Drug addiction
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Drug abuse.
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