JNTU
JNTU B.Pharmacy III BIOPHARMACEUTICS AND PHARMACOKINETICS Previous Question Paper (February - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
List out the different Mechanisms of drug absorption through GIT.
Answer
The primary mechanisms of drug absorption through the gastrointestinal tract include: 1) Passive diffusion, 2) Pore transport (convective transport), 3) Facilitated diffusion, 4) Active transport, 5) Ion-pair transport, and 6) Endocytosis (pinocytosis/phagocytosis).
Explain the factors affecting the protein drug binding.
Answer
Protein-drug binding is influenced by: 1) Drug-related factors, such as the physicochemical properties of the drug and its concentration; 2) Protein-related factors, including the concentration and quality of albumin or alpha-1-acid glycoprotein; and 3) Patient-related factors, such as age, disease states (e.g., renal or hepatic failure), and the presence of other drugs that may compete for binding sites.
Write the objective of Bioavailability studies.
Answer
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Write about Absolute Bioavailability.
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What is MRT and define it.
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Write about Biological half-life and its significance.
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What are the factors that determine the number of compartments for a given drug?
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Write equation and write importance of Vd.
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Define non-linear kinetics.
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Quote simple tests by which non-linear kinetics can be detected in a rate process.
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Part B
Explain pH partition theory along with its limitations.
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Explain the role of Blood Brain Barrier in drug distribution to the brain.
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Explain about plasma protein binding and its effect on drug distribution.
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Write about Phase-I Metabolic reaction with examples.
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Write about Level-I and Level-II Invitro- In vivo correlations.
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Explain the Methods used to calculate various Pharmacokinetic parameters from the Urinary Data when the drug follows one compartment kinetics.
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Write about physiological Model.
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Write the Advantages of Compartment models.
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Explain the phenomenon of drug accumulation during multiple doses.
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Give the equation for calculating plasma concentration, CSS and Cavg following repeated oral dose administration.
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How do you estimate the values of Km and Vmax in patients?
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Explain the reasons why we are getting Non-linearity in ADME of the drugs in the body with examples.
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