JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy IV NANO TECHNOLOGY Previous Question Paper (June - 2024 - R17)
Note: i) Question paper consists of Part A, Part B.
ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions.
iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Name some properties that make nano materials unique.
Answer
Nanomaterials exhibit unique properties due to their high surface-to-volume ratio, quantum confinement effects, and increased surface energy. Key properties include enhanced chemical reactivity, altered optical properties, superior mechanical strength, and increased electrical or thermal conductivity compared to their bulk counterparts.
Name the different types of nanoparticles with example.
Answer
Nanoparticles are classified based on their composition: 1) Polymeric nanoparticles (e.g., PLGA nanoparticles), 2) Metallic nanoparticles (e.g., Gold or Silver nanoparticles), 3) Lipid-based nanoparticles (e.g., Liposomes), and 4) Carbon-based nanomaterials (e.g., Carbon nanotubes).
Name some polymers used for preparation of polymeric nanoparticles.
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What are Niosomes? Give examples.
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Define Nano-thernostics.
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Difference between active and passive targeting using nanoparticles.
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What are the nanomaterials used in pulmonary drug delivery system?
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Mention three main advantages of nanoparticles in cardiovascular drug delivery?
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What is the formula for calculating drug entrapment and drug loading for nanoparticles?
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What is zeta potential? Explain the importance of it.
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Part B
Discuss the history of introduction of nanoparticles as a drug delivery vector in drug delivery technology.
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What are the most important properties of nanoparticles?
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Explain the effect of change of particle size in mechanical and optical properties of nanoparticles.
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Briefly explain about super para-magnetism in nanoparticles.
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Write briefly on magnetic features of Nanoparticles.
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Discuss in detail about the characterization of polymeric nanoparticles.
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Discuss the major drawbacks of polymeric nanoparticles in drug delivery and targeting?
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How has nanotechnology helped to improve medical treatment and diagnosis? Explain in details.
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How are nanoparticles used for drug targeting?
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Explain how nanoparticles target cells.
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What are the major factors and barriers in intranasl drug delivery?
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Discuss the role of nanoparticles in intra-nansal drug delivery?
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Critically analyze the major factors that should be considered before designing nanoparticles for drug delivery.
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How will you design a transdermal patch for a localized drug delivery?
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How to check the stability of nanoparticles?
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What are the factors that add to the instability of nanoparticles? Elaborate.
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What is the mechanism of drug release from nanoparticles?
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How do you measure drug release from nanoparticles?
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