JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Tech II PHYSICAL PHARMACY Previous Question Paper (February - 2024 - R22)
Note: This question paper contains two parts A and B. i) Part- A for 10 marks, ii) Part - B for 50 marks. Part-A is a compulsory question which consists of ten sub-questions from all units carrying equal marks. Part-B consists of ten questions (numbered from 2 to 11) carrying 10 marks each. From each unit, there are two questions and the student should answer one of them. Hence, the student should answer five questions from Part-B.
Part A
Explain Sorensen’s pH scale.
Answer
Sorensen’s pH scale is a logarithmic scale ranging from 0 to 14 used to specify the acidity or basicity of an aqueous solution. It is defined as the negative logarithm of the hydrogen ion concentration, providing a convenient way to express the wide range of H+ concentrations found in chemical and biological systems.
Write the equation for measurements of pH and write its importance.
Answer
The equation for pH is pH = -log[H+]. Its importance lies in determining the stability, solubility, and physiological compatibility of pharmaceutical formulations, as many drugs are weak acids or bases whose activity depends on the ionization state dictated by the pH of the medium.
What are different solute solvent interactions?
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Define and explain partition coefficient.
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Write the significance of interfacial phenomenon.
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Write importance of zeta potential.
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How particle shape influence Solubility?
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Write the importance of surface area of the particle.
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Define Suspension and Emulsions.
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Write applications of colloids.
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Part B
What are the factors influencing the pH of a buffer solution and brief note on preparation of buffer solutions?
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Write the methods of Adjusting tonicity and pH.
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What are the factors influencing solubility of liquids in liquids?
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Explain the influence of molecular association and dissociation on Partition coefficient.
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Explain distribution coefficient and Nernst distribution law.
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Write about interfacial and wetting phenomenon and their determination.
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What is Critical Surface tension and detergency phenomenon?
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Write rheological properties of Suspensions and Emulsions.
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Write the Factors influencing particle setting and physical stability of suspensions.
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Write different methods of determination of Surface area.
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What are the properties of powders and their significane?
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