JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD Pharm. D III Year PHARMACEUTICAL FORMULATIONS Previous Question Paper (October/November - 2019 - R08)

Wet granulation involves the addition of a liquid binder to a powder mixture to form granules, whereas dry granulation uses mechanical compression (slugging or roller compaction) to form granules without liquid.

The quality control tests for uncoated tablets ensure consistency, safety, and bioavailability. These include:

• General Appearance: Visual inspection for size, shape, color, surface texture, and identification markings.
• Hardness Test (Crushing Strength): Measures the force required to break the tablet using testers like the Monsanto or Pfizer hardness tester.
• Friability Test: Evaluates the tablet's resistance to mechanical shock and abrasion using a Roche friabilator; weight loss should ideally be less than 1%.
• Weight Variation Test: Ensures uniformity of dosage by weighing 20 tablets individually and calculating the percentage deviation from the average weight.
• Thickness and Diameter: Measured using a micrometer or vernier caliper to ensure uniformity within ±5%.
• Disintegration Test: Determines the time required for the tablet to break into particles in a liquid medium at 37°C using a disintegration apparatus.
• Dissolution Test: Measures the rate and extent of drug release from the tablet into a dissolution medium under standardized conditions.