JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The subject has been designed to make the students understand different

categories of inorganic drugs/ compounds which are used as medicinal agents

Course Outcome

The knowledge gained by the student after studying the subject in detailed

manner will be applicable to study and understand the concepts for higher classes.

UNIT - I

• 1. Classification of Inorganic Pharmaceuticals based on their applications and therapeutic uses.
• 2. Sources of impurities in pharmaceutical substances.
• 3. Test for purity
• a) Setting property of plaster of paris
• b) Ammonium compounds in sodium bicarbonate
• c) Oxalate in sodium citrate.
• d) Barium and thiocynate in Ammonium chloride
• 4. Qualitative tests for anion and cations
• 5. Limit tests for arsenic, heavy metals, lead, iron, chloride and sulphate.

Note

Definition, Preparation, Assay principle, Limit tests and Uses of the compounds

mentioned in Unit II to Unit V

UNIT - II

• 1. Electrolytes:
• a) Sodium and Potassium replenishers: Sodium chloride, compound sodium chloride solution (Ringer solution), potassium chloride, ORS.
• b) Calcium replenishers: Calcium gluconate, dibasic calcium phosphate, calcium chloride.
• 2. Acid base regulators: Sodium bicarbonate, sodium lactate, sodium citrate/potassium citrate, sodium acetate, and ammonium chloride
• 3. Dialysis fluids: Haemodialysis fluids.

UNIT - III

Gastro-intestinal agents.

• 1. Acidifiers and Antacids: Dilute hydrochloric acid, sodium acid phosphate, sodium bicarbonate, aluminium hydroxide gel, dried aluminium hydroxide gel, magnesium oxide (Magnesia), magnesium hydroxide mixture, magnesium trisilicate.
• 2. Adsorbents and related drugs: Light kaolin, heavy kaolin, and activated charcoal.
• 3. Laxatives: Magnesium sulphate, sodium phosphate.
• 4. Mineral Nutrients / Supplements
• a) Haematinics – Ferrous sulphate, ferrous fumarate, ferrous gluconate, ferric ammonium citrate, iron and dextrose injection.
• b) Halogens: Iodine, Iodides.
• 5. Pharmaceutical aids:
• a) Excipients: Dicalcium phosphate, magnesium stearate, talc and calcium carbonate (Precipitated chalk).
• b) Suspending agents: Bentonite, colloidal silica.
• c) Colorants: Titanium oxide, Ferric oxide

UNIT - IV

• a) Expectorants: Ammonium chloride, potassium iodide.
• b) Emetics: Potassium antimony tartarate, copper sulphate.
• c) Antidotes: Sodium thiosulphate, sodium nitrite. Topical agents:
• 1. Astringents: Zinc sulphate, calcium hydroxide, Bismuth sub carbonate.
• 2. Topical protectants: Zinc oxide, calamine, zinc stearate, talc, titanium-dioxide, heavy kaolin and light kaolin (only uses).
• 3. Silicone polymers: Activated dimethicone.
• 4. Anti-Infectives: Hydrogen peroxide solution, potassium permanganate, silver nitrate (silver protein), iodine, (solutions of iodine, povidone iodine), boric acid, zinc undecylenate, mercury compounds (yellow mercuric chloride)

UNIT - V

Dental products:

• 1. Fluorides: Sodium fluoride, sodium monofluorophosphate and stannous fluoride.
• 2. Oral antiseptics and Astringents: Hydrogen peroxide, magnesium, peroxide, zinc peroxide and mouth washes.
• 3. Dentifrices: Calcium carbonate, dibasic calcium phosphate, calcium phosphate, sodium metaphosphate and strontium chloride.
• 4. Cements & fillers : Zinc oxide (only uses). Miscellaneous Medicinal Agents
• a) Antineoplastics : Cisplatin
• b) Antidepressants : Lithium carbonate
• c) Diagnostic agents : Barium sulphate
• d) Surgical Aids : Plaster of Paris
• e) Antirheumatic agents : Sodium aurothiomalate
• f) Internal parasiticid : Sodium antimony gluconate
• g) Anti thyroid agents : Potassium perchlorate

TEXT BOOKS

• 1. A. H. Beckett and J. B. Stenlake, Practical pharmaceutical chemistry, Part-I. The Athtone press,
• 2. University of London, London.
• 3. P. Gundu Rao, Inorganic pharmaceutical chemistry; Vallabh Prakashan, Delhi.
• 4. Advanced Inorganic Chemistry by Satya Prakash, G. D. Tuli

REFERENCES

• 1. L.M. Atherden, Bentley and Driver’s Textbook of Pharmaceutical Chemistry Oxford University Press, London.
• 2. Indian Pharmacopoeia 1996, 2006.