JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Overview

I. Synthesis of some simple heterocyclic compounds.

• a. 3, 5-Dimethylpyrazole from Acetylacetone.
• b. 3, 5-Dimethylisoxazole from Acetylacetone.
• c. 4, 5-Diphenylimidazole from Benzil.
• d. Benzoxazole from o-Aminophenol.
• e. 2, 5-Dioxopiperazine from Glycine.
• f. Oxazolone from Benzoylglycine. II. Molecular rearrangements and named reactions
• a. Benzimidazole from o-phenylenediamine (Phillip’s Reaction).
• b. O-hydroxyacetophenone from phenyl acetate (Fries migration)
• c. Benzanilide from benzophenone oxime (Beckmann’s rearrangement)
• d. Preparation of 2-phenylindole from Phenylhydrazine by Fischer’s method. III. Systematic analysis of organic binary mixtures (Minimum 4 numbers)

REFERENCES:

• 1. Indian Pharmacopoeia– 2010.
• 2. A.I. Vogel’s – Practical Organic Chemistry
• 3. Mann and Sounders, Pratical organic chemistry