JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The student shall be taught on industrial phenomenon of liquids, rate &

order of reactants, micromeritics, flow of liquids and type of colloids and their properties.

UNIT - I

Kinetics: Rates and orders of the reaction. Influence of temperature and other factors on reaction rates. Decomposition and stabilization of medicinal agents, kinetics in the solid state and accelerated stability analysis (relevant numerical problems).

UNIT - II

• a. Interfacial Phenomena: Liquid interfaces, measurement of surface and interfacial tensions, adsorption at liquid interfaces. Surface-active agents and HLB scale. Adsorption at solid interfaces. Electrical properties of interfaces.
• b. Colloids: Introduction, types of colloidal systems, solubilization, Stability of colloids, optical properties, kinetic properties, electrical properties and Donnan Membran equilibraium.

UNIT - III

Micromeritics: Particle size and size distribution, methods for determining surface area, methods for determining practicle size, pore size, particle shape and surface area, derived properties of powders.

UNIT - IV

Rheology: Newtons law of flow, Newtonian systems, non-Newtonian systems, thixotropy, measurement and applications in formulations. Determination of viscosity (study of working of different viscometers like cup and bob, Brookfield, ostwald’s, cone and plate, capillary viscometers) and its applications.

UNIT - V

Coarse Dispersions: Suspensions: Types of suspensions, interfacial properties of suspended particles, stability evaluation, settling in suspensions, formulation of suspensions. Emulsions: Theories of emulsification, physical stability of emulsions, preservation of emulsions, rheological properties of emulsions and suspensions.

Outcome: Student will know about influence of temperature and other factors on rate of reactants, interfacial phenomena, particle size & distribution, Newtonian and Non-Newtonian flows.

TEXT BOOKS

• 1. Patrick J. Sinko, Martin's Physical Pharmacy and Pharmaceutical Sciences 5th Edition.
• 2. CVS Subhramanyam, Physical Pharmacy, Vallabh prakashan.
• 3. L. Lachman, H. Lieberman The Theory And Practice Of Industrial Pharmacy J. L Kaniz Lee & Febiger Philadelphia, USA

REFERENCE

• 1. Lippincott Williams and Wilkins, Remington Pharmaceutical Sciences
• 2. M.E. Aulton, Pharmaceutics –The science of dosage form design, 2nd edn