JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The student shall be taught on preformulation factors and objectives of

preformulation, stability and Bioavailability of formulation, concept of products, semisolids, aerosols and cosmetic preparations.

Course Outcome

Student will know the preformulation parameters in designing the dosage form,

ICH guidelines, preparation and evaluation of semisolids, ophthalmic and cosmetics.

UNIT - I

Preformulation:

• a. Introduction and objectives of preformulation study and development of dosage forms, Physical and Chemical aspects.
• b. Stability and bioavailability study of prodrugs in solving problems related to stability bio availability in formulations.
• c. Stability testing of finished products as per ICH guidelines.

UNIT - II

• a) Tablets: Formulation and evaluation of tablets: Conventional, matrix, chewable, multi-layered tablets, buccal and sublingual, fast dissolving tablets and gastric retention drug delivery systems
• b) Machinery used in granulation techniques like rapid mixer granulation, fluidised bed systems and tablet compression

UNIT - III

Coating of Tablets: Types of coating, coating materials and their selection, formulation of coating solution, equipment for coating, coating processes and evaluation of coated tablets. Pellet technology

UNIT - IV

• a) Capsules: Advantage and disadvantages of capsule dosage forms, material for production of hard and soft gelatin capsules, sizes of capsules, capsule filling, processing problems in capsule manufacturing, importance of base absorption and minimum/gm factors in soft capsules, quality control, stability testing and storage of capsule dosage forms.
• b) Microencapsulation: Types and importance in pharmacy, microencapsulation by coacervation phase separator, multi orifice centrifugal separation. Spray drying, spray congealing, polymerization complex emulsion, air suspension technique, and pan coating techniques and evaluation of microcapsules.

UNIT - V

Cosmeticology and Cosmetic Preparations: Fundamentals of cosmetic science, Formulation, preparation and packaging of cosmetics for skin, hair, dentrificers like tooth powders, paste, gels and manicure preparations like nail polish, lipsticks, eye lashes, baby care products etc.

TEXT BOOKS

• 1. L. Lachman, H.A, Lieberman and J.L. Kanig, Theory & Practice of industrial Pharmacy, Lea & Febieger, Philadelphia Latest Edn.
• 2. CVS. Subramanyam, Pharmaceutical production and management, Vallabh Prakashan, New Delhi 2005.
• 3. Lippincott Williams and Wilkins, Remington Pharmaceutical Sciences.

REFERENCES

• 1. Shobha Rani, Text of Industrial Pharmacy, Hiremath Orient Longman
• 2. Essentials of pharmaceutical technology by Ajay semelty, Mona Semalty