JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

Student will know the formulation and evaluation of tablets, coated tablets,

capsules, micro-encapsules and parenteral preparations in laboratories and industrial scale.

Course Outcome

The students shall be exposed to various aspects of pharmaceutical product

preparations and evaluations of tablets, capsules etc.

UNIT - I

Semisolid dosage forms: Definitions, types, mechanisms of drug penetration, factors influencing penetration, semisolid bases and their selection. General formulation of semi solids, clear gels manufacturing procedure, evaluation and packaging.

UNIT - II

• a. Pharmaceutical aerosols: Definition, propellants general formulation, manufacturing and packaging methods, pharmaceutical applications and evaluation.
• b. Dry Syrups, Formulation, Preparation, Evaluation and special applications with examples.

UNIT - III

Parenteral Products

• a. Preformulation factors, routes of administration, water for injection, treatment apyrogenicity, non- aqueous vehicles, isotonicity and methods of its adjustment.
• b. Formulation details, container and closures and selection.
• c. Prefilling treatment, washing and sterilization of containers and closures, preparation of solution and suspensions, filling and closing of ampules, vials, infusion flulids, lyophillization & preparation of sterile powders, equipment for large-scale manufacture and evaluation of parenteral products. Opthalmic Preparations: Requirements, formulation, methods of preparation, containers and evaluation.

UNIT - IV

Aseptic techniques, sources of contamination and method of prevention. Design of aseptic area, laminar flow benches, services and maintenance.

UNIT - V

• a. Packaging of Pharmaceutical products: Packaging components, types, specifications and methods of evaluation as per I.P. Factors influencing choice of containers, package testing, legal and other official requirements for containers, packing testing.
• b. Methods of packing of solid, liquid and semi-solid dosage forms, Factors influencing packing material and stability aspects of packaging.

TEXT BOOKS

• 1. L. Lachman, H.A, Lieberman and J.L. Kanig, Theory & Practice of industrial pharmacy, Lea & Febieger, Philadelphia Latest Edn
• 2. HC Ansel introduction to Pharmaceutical Dosage forms
• 3. CVS. Subramanyam, Pharmaceutical production and management, Vallabh Prakashan, New Delhi 2005.

REFERENCES

• 1. Sagarian & MS Balsam, Cosmetics Sciences &Technology,Vol.1, 2 & 3
• 2. Lippincott Williams and Wilkins, Remington Pharmaceutical Sciences