JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The chemistry including the structure elucidation of the natural products

belonging to different groups such as amino acids, alkaloids, carbohydrates, steroids etc. are discussed in depth.

Course Outcome

The knowledge of the students is enhanced with the clear information about the

natural products which are having medicinal importance.

UNIT - I

Poly Functional Natural Products

• (a) Carbohydrates: Introduction, Definition, Classification, Isolation, General Properties (including isomerism) and Pharmaceutical importance of Carbohydrates, Chemistry (Structme, Nomenclatme and Reactions) of glucose, fructose, sucrose, maltose, cellulose and starch.
• (b) Oils & Fats: Introduction, Definition, Classification, Isolation, General properties and Pharmaceutical importance of oils and fats. Chemistry (structure, nomenclature and reactions) of oils and fats and analysis according to Pharmacopoeial methods

UNIT - II

Amino Acids and Proteins Introduction, definition, classification, isolation, general properties and pharmaceutical importance of amino acids and their relationship to proteins and polypeptides. Chemistry of Protein Hormones: Insulin, Oxytocin, Thyroxin and Anti-thyroid drugs

UNIT - III

• a. Flavonoids: Sources, uses, chemistry and General methods of structural determination (chemical & spectral analysis) of Amygdalin, arbutin and quercetin
• b. Terpenoids: Definiton and Classification: Isoprene rule, Special Isoprene rule for terpenes, General methods of isolation. Chemistry and structure elucidation of citral, menthol and camphor.

UNIT - IV

• a. Alkaloids Introduction, definition, occurence, classification, isolation, general properties and pharmaceutical importance of alkaloids. General methods of extraction, structure elucidation and chemistry (structure, nomenclatme and reactions) of ephedrine, atropine, papaverine and quinine b.Purine and Xanthine Derivatives Chemistry and Pharmaceutical importance Caffeine, Theophylline, Theobromine and Uric acid.

UNIT - V

Steroids Introduction, Definition, Occurence, Classification, Isolation, General properties and Pharmaceutical importance of Sterols: color reactions of cholesterol, stigmasterol, ergosterol. Importance & general concepts of bile acids. Steroidal saponins: Diosgenin and hecogenin. Androgens, Estrogens, Progestational agents, Steroidal contraceptives. Adrenocorticoids, Deoxycorticosterone, Cortisone, Prednisone, Aldosterone. Cardiac Glycosides of Digitalis other Cardiac drugs, Strophanthus and Squill.

TEXT BOOKS

• 1. Organic Chemistry, Vol.II by I.L. Finar, The English Language Book Society, London.
• 2. Natural Products Vol.I & II by O.P. Agarwal Goel publications – Meerut.
• 3. F.G.Mann & B. Saunders, Practical Organic Chemistry Longamans Green & Co. Ltd., U.K

REFERENCE BOOKS

• 1. Burger’s Medicinal Chemistry, M.E. – Wolff, Ed., John Wiley & Sons, New York.
• 2. R. M. Acheson, An Introduction to the Chemistry of Heterocyclic Compounds, Interscience NY.