JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

Emphasizes on the conceptual background and development of medicinal

chemistry and drug design. Identification of lead for new drug design. Modification of lead aimed at changing Pharmacodynamic and Pharmacokinetics.

Course Outcome

The students would be in a position to identify lead for new drug design, to design

and discover the novel drus with the knowledge they gained through the study of the various topics of the syllabus.

Basic principles, salient features and applications for the following units:

UNIT - I

Introduction of modern drug discovery concept and technologies.

UNIT - II

Principles of combinatorial chemistry.

UNIT - III

Introduction to structure based drug design.

UNIT - IV

Molecular modelling and drug design.

UNIT - V

QSAR.

TEXT BOOKS

• 1. Textbook of Drug Design and Discovery, 4th Ed.,by Larsen
• 2. Structure-based Drug Discovery by Jhoti, Harren
• 3. William H, Malick JB “Drug Discovery and Development” Humana Press Clifton.

REFERENCE

• 1. Robert GCK, ed., “Drug Action at the Molecular Level” University Prak Press Baltimore.
• 2. Martin YC. “Quantitative Drug Design” Dekker, New York.