JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

- The students is going to study about various techniques for screening of drugs

for various pharmacological activities and guide lines for handling animals and human and animal ethics for screening of drugs.

Course Outcome

- The expected outcomes are student will know how to handle animals and know

about various techniques for screening drugs for different pharmacological activities and guidelines and regulations for screening new drug molecules on animals and human volunteers.

UNIT - I

Care Handling and breeding techniques of laboratory animals, CPCSEA guidelines, alternatives to animal studies, Good laboratory Practices.

UNIT - II

Bioassays: Basic principles of Biological standardization, Merits and demerits, methods used in the bio-assay of Rabbis Vaccine and Oxytocin. Test for pyrogens.

UNIT - III

Toxicity tests: OECD guidelines, determination of LD50, acute, subacute and chronic toxicity studies.

UNIT - IV

Screening: Definition, types of screening methods. Pharmacological activity of new substances with emphasis on the evaluation of analgesic, antipyretic and anti-inflammatory activity.

UNIT - V

Screening for the Pharmacological activity of epilepsy, cardiac, psychopharmacological, anti diabetic and anticancer.

TEXT BOOKS

• 1. Screening methods in Pharmacology, Vol.-1&2 by Robert .A. Turner and Peter Hebborn.
• 2. Pharmacological Screening Methods & Toxicology by Srinivasa Rao A,Pharmamed press publishers.
• 3. Handbook of experimental pharmacology by S.K. Kulkarni, Vallabh Prakashan, Delhi.

REFERENCE BOOKS

• 1. ICH of technical requirements for registration of pharmaceuticals for human use, ICH harmonized Tripartite guidelines - Guidelines for good clinical practice, E6, May 1996.
• 2. Good clinical practice - Guidelines for Clinical trails on pharmaceutical products in India, Central drug standard control organization, New Delhi, Minister of Health- 2001