JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

PS608: MEDICINAL CHEMISTRY – I LAB

B.Pharmacy III Year II Semester (R16)

Overview

  • i. Synthesis of some medicinal compounds and their analogues.
  • a. Barbituric acid from Diethyl Malonate.
  • b. Phenytion from Benzoin or Benzil.
  • c. Paracetomol from para- nitro phenol or para- aminophenol.
  • d. 1,4- di hydro pyridine from ethyl aceto acetate.
  • e. Quinazolinone from anthranilic acid via benzoxazinone.
  • f. Systhesis of Finofibrate
  • g. Isoniazid from -picoline.
  • h. Antipyrine from ethyl aceto acetate.
  • i. Benzocaine from para- nitro benzoic acid.
  • ii. Qualitative estimation of some functional groups. *
  • a. Halogens (Strepheno’s method).
  • b. Hydroxyl groups (acetylation method)
  • c. Methoxyl groups (Zeissel’s method)
  • d. Carboxyl groups (silver salt method).

REFERENCES

  • 1) A.I. Vogel, Text Book of Practical Organic Chemistry, 5th Edition.
  • 2) R.K. Bansal, Laboratory Manual of Organic Chemistry. th
  • 3) F.G. Mann & B.C. Saunders, Pratical Organic Chemistry, 4 Edition.
  • 4) Advacned medicinal chemistry lab guide by N. Raghu Prasad and M. Raghuram Rao
  • 5) Organic chemistry a Lab manual, Cengage learning India Pvt. Ltd. By Pavia

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