JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

This course is designed to impart knowledge on controlled drug delivery systems

including oral, transdermal, mocuadhesive, targeted (Liposomes and Nanoparticles). It also helps to know how regulatory agencies (Indian CDSCO, USFDA, Canadian HPFBI and Australian TGA) act on release of NDA & ANDA.

Course Outcome

Student shall be able to know the controlled, sustained drug delivery systems,

their methods of preparation.

UNIT - I

Oral Control Drug Delivery Systems: Fundamental study of different types of Oral Contolled drug delivery systems, sustained release concept, design of sustained release dosage form, Zero order release, first order release approximation, multiple dosing. Dissolution Controlled, Diffusion Controlled, Ion Exchange Resins, Osmotic based systems, pH Independent Systems.

UNIT - II

• a. Transdermal Drug Delivery Systems: Fundamentals, types of TDDS, Materials Employed and Evaluation of TDDS.

UNIT - III

Mucoadhesive Delivery Systems: Mechanism of bioadhesion, mucoadhesive materials, forumulation and development of mucoadhesive-based systems.

UNIT - IV

Targeted Drug Delivery Systems: Fundamentals and applications, formulation and evaluation of liposomes, resealed erythrocytes and nano particles.

UNIT - V

Introduction, principle and Fabrication of Intrauterine Devices / injections / implants

TEXT BOOKS

• 1. Novel drug delivery system by Prof. (Dr) A.K. Bandyopadhyay
• 2. N.K. Jain, Control Drug Delivery Systems by
• 3. Y.Anjaneyulu & Maraiah, Quality Assurance & Quality Management in Pharmaceutical Industry.

REFERENCES

• 1. Leon Shargel Isadore Kanfer, Generic Drug Product Development, Solid Oral Dosage Forms, Marcel Dekker.
• 2. Sagarian & MS Balsam, Cosmetics Sciences &Technology.Vol.1, 2 & 3 R16 B.PHARMACY IV YEAR