JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The student is going to study about various techniques involved in screening of

drugs for various pharmacological activities and guidelines for handling animals

Course Outcomes

This subject is designed to impart the knowledge on preclinical evaluation of drugs

and recent experimental techniques in the drug discovery and development. The subject content helps the student to understand the maintenance of laboratory animals as per the guidelines. The expected outcome are – the students will know how to handle animals and know about various techniques for screening of drugs for different pharmacological activities and guidelines for regulations involved in screening of new drug molecules on animals.

UNIT - I

Care, handling and breeding technique of laboratory animals. Regulations for laboratory animals, CPSCEA guidelines, alternative to animal studies.

UNIT - II

Toxiciy test: OECD guidelines, determination of LD50, acute, sub-acute and chronic toxicity studies.

UNIT - III

Organization of screening for pharmacological activity of new substances with emphasis on the evaluation of antipsychotics, antiepileptics and antidepressants.

UNIT - IV

Screening methods for anti-diabetic, antiulcer, CHF and anti-hypertensive drugs.

UNIT - V

Screening methods for anti-inflammatory, analgesics and antipyretic drugs.

Recommended Books (Latest edition):

• 1. Biological standardization by J.H. Burn D.J. Finney and I.G. Goodwin.
• 2. Screening methods in Pharmacology by Robert Turner. A.
• 3. Methods in Pharmacology by Arnold Schwartz.
• 4. Pharmacological screening methods and Toxicology by A Srinivasa Rao and N.Bhagya Lakshmi
• 5. Fundamentals of experimental Pharmacology by M.N. Ghosh.
• 6. Experimental Pharmacology for undergraduates by M C Prabhakara.
• 7. Drug discovery and Evaluation by Vogel H.G.
• 8. Experimental Pharmacology by R.K. Goyal.
• 9. Preclinical evaluation of new drugs by S.K. Gupta.
• 10. Handbook of Experimental Pharmacology, SK. Kulkarni.
• 11. Practical Pharmacology and Clinical Pharmacy, SK. Kulkarni, 3rd Edition.
• 12. Screening Methods in Pharmacology, Robert A. Turner. R17 B. PHARMACY III YEAR PS609: MEDICINAL CHEMISTRY- III LAB B.Pharm. III Year II Sem. L T/P/ C 0 0/4/ 2
• 1. Preparation of drugs and intermediates
• a. Sulphanilamide
• b. 7-Hydroxy, 4-methyl coumarin
• c. Chlorobutanol
• d. Triphenyl imidazole
• e. Tolbutamide
• f. Hexamine
• 2. Assay of drugs
• a. Isonicotinic acid hydrazide
• b. Chloroquine
• c. Metronidazole
• d. Dapsone
• e. Chlorpheniramine maleate
• f. Benzyl penicillin
• 3. Preparation of medicinally important compounds or intermediates by Microwave irradiation technique
• 4. Drawing structures and reactions using chem draw®
• 5. Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5) Recommended Books (Latest Editions)
• 1. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry.
• 2. Foye’s Principles of Medicinal Chemistry.
• 3. Burger’s Medicinal Chemistry, Vol I to IV.
• 4. Introduction to principles of drug design- Smith and Williams.
• 5. Remington’s Pharmaceutical Sciences.
• 6. Martindale’s extra pharmacopoeia.
• 7. Organic Chemistry by I.L. Finar, Vol. II.
• 8. The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5.
• 9. Indian Pharmacopoeia.
• 10. Text book of practical organic chemistry- A.I.Vogel. R17 B. PHARMACY III YEAR