JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

This subject is designed to impart basic knowledge on the area of novel drug

delivery systems.

Course Outcomes

Upon completion of the course student shall be able:

• To understand various approaches for development of novel drug delivery systems.
• To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation

UNIT - I

• 1. Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
• 2. Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.

UNIT - II

• 1. Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications
• 2. Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems
• 3. Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, concept of implantsand osmotic pump

UNIT - III

• 1. Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
• 2. Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications
• 3. Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

UNIT - IV

Nanotechnology and its Concepts: Concepts and approaches for targeted drug delivery systems, advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

UNIT - V

• 1. Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome – Preliminary study, ocular formulations and ocuserts
• 2. Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications R17 B. PHARMACY IV YEAR Recommended Books: (Latest Editions)
• 1. Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.
• 2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.
• 3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
• 4. N. K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, 1st edition 1997 (reprint in 2001).
• 5. S. P. Vyas and R. K. Khar, Controlled Drug Delivery - concepts and advances, Vallabh Prakashan, New Delhi, 1st edition 2002. R17 B. PHARMACY IV YEAR