JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

This course is designed to impart a fundamental knowledge on the art and scienceof

various unit operations used in pharmaceutical industry.

Course Outcomes

Upon completion of the course student shall be able:

• To know various unit operations used in Pharmaceutical industries.
• To understand the material handling techniques.
• To perform various processes involved in pharmaceutical manufacturing process.
• To carry out various test to prevent environmental pollution.
• To appreciate and comprehend significance of plant lay out design for optimum use of resources.
• To appreciate the various preventive methods used for corrosion control in Pharmaceutical industries.

UNIT - I

Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and Rotometer. Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill. Size Separation: Objectives, applications & mechanism of size separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.

UNIT - II

Mixing: Objectives, applications & factors affecting mixing, Difference betweensolid and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender, ribbon blender, Sigma blade mixer, planetary mixers, Propellers, Turbines, Paddles & Silverson Emulsifier, Crystallization: Objectives, applications, & theory of crystallization. Solubilitycurves, principles, construction, working, uses, merits and demerits of Agitated batch crystallizer, Swenson Walker Crystallizer, Krystal crystallizer, Vacuum crystallizer. Caking of crystals, factors affecting caking & prevention of caking.

UNIT - III

Evaporation: Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator& Economy of multiple effect evaporator. Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’slaw, Heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers. List of equipment by name and their functions.

UNIT - IV

Drying: Objectives, applications & mechanism of drying process, measurements& applications of Equilibrium Moisture content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer. Distillation: Objectives, applications & types of distillation. principles, construction, working, uses, merits and demerits of (lab scale and industrial scale) Simple distillation, preparation of purified water and water for injection BP by distillation, flash distillation, fractional distillation, distillation under reduced pressure, steam distillation & molecular distillation

UNIT - V

Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter, membrane filters and Seitz filter. HEPA filters for controlled pollution.

Centrifugation: Objectives, principle & applications of Centrifugation, principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge.

RECOMMENDED BOOKS: (Latest Editions)

• 1. Introduction to chemical engineering – Walter L Badger & Julius Banchero, Latest edition.
• 2. Solid phase extraction, Principles, techniques and applications by Nigel J.K. Simpson-Latest edition.
• 3. Unit operation of chemical engineering – Mcabe Smith, Latest edition.
• 4. Pharmaceutical Engineering DK Tripathi, Pharma Med Press
• 5. Pharmaceutical engineering principles and practices – C.V.S Subrahmanyam et al., Latest edition.
• 6. Remington practice of pharmacy- Martin, Latest edition.
• 7. Theory and practice of industrial pharmacy by Lachmann., Latest edition.
• 8. Physical pharmaceutics- C.V.S Subrahmanyam et al., Latest edition.
• 9. Cooper and Gunn’s Tutorial pharmacy, S.J. Carter, Latest edition.
• 10. Derle, Essentials of Pharmaceutical Engineering (Unit Operations), 2nd Ed. Pharma Med Press