JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Overview

Scope: This subject deals with the monographs of inorganic drugs and pharmaceuticals.

Course Objectives

Upon completion of course, student shall be able to

• know the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals
• understand the medicinal and pharmaceutical importance of inorganic compounds

UNIT - I

Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate General methods of preparation, assay for the compounds superscriptedwith asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes

UNIT - II

Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity. Major extra and intracellular electrolytes: Functions of majorPhysiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance. Dental products: Dentifrices, role of fluoride in the treatment of dentalcaries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

UNIT - III

Gastrointestinal agents Acidifiers: Ammonium chloride* and Dil. HCl Antacid: Ideal properties of antacids, combinations of antacids, SodiumBicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin andBentonite Antimicrobials: Mechanism, classification, Potassium permanganate, Boricacid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations

UNIT - IV

Miscellaneous compounds Expectorants: Potassium iodide, Ammonium chloride*. Emetics: Copper sulphate*, Sodium potassium tartarate Haematinics: Ferrous sulphate*, Ferrous gluconate Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodiumnitrite333 Astringents: Zinc Sulphate, Potash Alum

UNIT - V

Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of á, â, ã radiations, Half life, radio isotopes and study of radio isotopes - Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.

TEXT BOOKS

(Latest Editions)

• 1. A.H. Beckett & J.B. Stenlake's, Practical Pharmaceutical Chemistry Vol I & II, Stahlone Press of University of London, 4th edition.
• 2. A.I. Vogel, Text Book of Quantitative Inorganic analysis
• 3. P. GunduRao, Inorganic Pharmaceutical Chemistry, 3rd Edition
• 4. M.L Schroff, Inorganic Pharmaceutical Chemistry
• 5. Bentley and Driver's Textbook of Pharmaceutical Chemistry
• 6. Anand&Chatwal, Inorganic Pharmaceutical Chemistry
• 7. IndianPharmacopoeia
• 8. Algarsamy V. Pharmaceutical Inorganic Chemistry, 2nd Ed. Pharma Med Press
• 9. Rao Somasekhar, Pharmaceutical Inorganic Chemistry, Pharma Med Press