JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Pre-requisites

Nil

UNIT - I

Bio-Fluid Mechanics: Newton’s laws, Stress, Strain, Elasticity, Hooke’s-law, viscosity, Newtonian fluid, Non- Newtonian fluid, Viscoelastic fluids, vascular tree, Relationship between diameter, velocity and Pressure of blood flow, Resistance against flow. Flow Properties of Blood: Physical, chemical and Rheological properties of blood. Apparent and Relative viscosity. Blood viscosity variation: Effect of shear rate, Hematocrit, Temperature, Protein content of blood. Casson’s Equation, Problems associated with extracorporeal blood flow

UNIT - II

Rheology of Blood in Microvessels: Fahraeus - Lindqvist effect and inverse effect, distribution of suspended particles in a narrow rigid tube. Nature of red cells in tightly fitting tubes, hematocrit in very narrow tube Bioviscoelastic Fluid: Viscoelasticity, Viscoelastic models Maxwell, Voigt and Kelvin Models and simulation in Matlab, Response to Harmonic variation, and Use of viscoelastic models. Bioviscoelastic fluids: Protoplasm, Mucus, Saliva, Synovial fluids

UNIT - III

Cardiac Mechanics: Cardiovascular system. Mechanical properties of blood vessels: arteries, arterioles, capillaries, and veins. Blood flow: Laminar and Turbulent, Physics of cardiovascular diseases, Prosthetic heart valves and replacements.

UNIT - IV

Respiratory Mechanics: Alveoli mechanics, Interaction of Blood and Lung, Mathematical model Lung Ventilation. P.V curve of Lung. Breathing mechanism, Airway resistance, Physics of Lung diseases. Soft Tissue Mechanics: Pseudo elasticity, Non-Linear stress-strain relationship, Structure, Function and mechanical properties of skin, ligaments, and tendons

UNIT - V

Orthopedic Mechanics: Mechanical properties of Cartilage, Diffusion properties of articular cartilage, Mechanical properties of Bone, Kinetics, and Kinematics of joints, Lubrication of Joints.

R16 B.TECH BIOMEDICAL ENGG.

TEXT BOOKS:

• 1. Y.C Fung, Biomechanics- Mechanical properties of living tissues, 2nd Edn, Springer- Verlag, 1993.
• 2. D.O Cooney, Biomedical engineering Principles. Marcel Dekker, INC New York. 1976.

REFERENCE BOOKS:

• 1. Silver Frederick H. Biomaterials, Medical Devices & Tissue Engineering: Chapman & Hall, London, 1994
• 2. Biomechanics by Nihat ozkaya and Margareta Nordin
• 3. D.A Mc Donald, Blood flow in arteries, Edward Arnold ltd, 1998. R16 B.TECH BIOMEDICAL ENGG.