JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Pre-requisites

Nil

UNIT - I

The problem of system modeling in Physiology: Types of Nonlinear models of physiological systems. Deductive and Inductive modeling. Nonparametric modeling: Volterra models. Wiener models. Efficient volterra kernel estimation Analysis of estimation errors.

UNIT - II

Parametric modeling: Basic parametric model forms and Estimation procedures. Volterra kernels of nonlinear differential equations. Discrete-time volterra kernels of NARMAX models. From Volterra kernel measurements to parametric models. Equivalence between continuous and Discrete -parametric models.

UNIT - III

Preliminary tests and Data preparation: Model specification and Estimation. Model validation and Interpretation. Outline of step-by-step procedure. Applications: Neurosensory systems: Cardiovascular system, Renal system, Metabolic- Endocrine system.

UNIT - IV

Modeling of multi input/multi output systems: The Two-input case. Application s of two- input modeling to physiological systems. The Multiinput case spatiotemporal and spectrotemporal modeling.

UNIT - V

Modeling of neuronal systems: A General model of membrane and Synaptic dynamics, Functional integration in the Single neuron, Neuronal systems with Point process inputs Modeling of neuronal ensembles. Modeling of Closed-loop systems: Autoregressive form of Closed-loop model, Network model form of Closed-loop systems.

TEXT BOOKS:

• 1. Vasilis Z. Marmarelis, Nonlinear dynamic modeling of physiological systems, Wiley- IEEE Press, 2004.

REFERENCE BOOKS:

• 1. David T. Westwick, Robert E. Kearney, Identification of Nonlinear Physiological Systems, Wiley-IEEE Press, 2003.
• 2. Michel C Khoo, Physiological Control Systems -Analysis, simulation and estimation, Prentice Hall of India, 2001. R16 B.TECH BIOMEDICAL ENGG.