JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives:

• To introduce the student to the range of biomaterials and the science and engineering of biomaterials.
• To understand constraints associated with the use of biomaterials.

Course Outcomes

After completing the course, the student will be able to:

• Explain the types of Biomaterials and their relative advantages and disadvantages
• Indicate the constraints placed on the use of materials in biological environments
• Explain the characterization of materials from the perspective of application as a biomaterial

UNIT - I

Introduction to basic concepts of Materials Science; Salient properties of important material classes. Property requirement of biomaterials; Concept of biocompatibility. Structure and properties of biological cells & tissues. Cell-material interactions and foreign body response.

UNIT - II

Assessment of biocompatibility of biomaterials. In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay). In vivo testing and histocompatibility assessment. Genotoxicity assessment (Physical damage to DNA by biomaterial eluates)

UNIT - III

Important bio-metallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys. Bio-inert, Bioactive and bioresorbable ceramics. Biocompatibility of Alumina & Carbon Nanotube Reinforced Hydroxyapatite. Glass -ceramics for dental restoration applications

UNIT - IV

Processing and properties of different bio-ceramic materials with emphasize on hydroxyapatite. Synthesis of biocompatible coatings on structural implant materials. Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility. Microstructure and properties of glass-ceramics. Biodegradable polymers.

UNIT - V

External field and cell – material interaction, Tissue Engineering and Wound healing. Design concept of developing new materials for bio-implant applications.

TEXT BOOKS:

• 1. Biomaterials Science: An introduction to Materials in Medicine, Edited by Ratner, Hoffman, Schoet and Lemons, Second Edition: Elsevier Academic Press, 2004.
• 2. Comprehensive structural interity, Vol.9: Bioengineering Editors: Mithe, Ritchie and Karihalo, Elsevier Academic Press, 2003.

REFERENCE BOOKS:

• 1. Biomaterials Science and Biocompatability, Fredrick H. Silver and David L. Christiansen, Piscataway, Springer, New Jersey.
• 2. Biological Performance of Materials: Fundamentals of Biocompatibility, Janathan Black, Marcel Dekker, Inc., New York and Basel, 1981.
• 3. Basic Cell Culture: A Practical Approach, Edited by J.M. Davis, IRL Press, Oxford University Press, New York, 1994.