JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

The contents of Unit I mainly aimed to identify lead molecules from the natural

sources. The contents of Unit II &III are mainly designed to have the knowledge of alkaloids and steroids especially structural elucidation of few important compounds. The contents of Unit IV and V are to offer an understanding of utilization of natural products for the preparation of new molecules for the treatment of different diseases like cancer, malaria etc.

Course Outcome

The student would be in a position to explore the natural lead compounds for the

treatment of different diseases like cancer, malaria, diabetes etc.

UNIT - I

Natural products as leads for new drugs: Introduction/history, approaches to discovery and development of natural products as potential new drugs selection and optimization of lead compounds for further development with suitable examples from antibiotics, CNS, and cardiovascular agents.

UNIT - II

Alkaloids: Introduction and general methods of structure elucidation. From opium: morphine-structure elucidation, development of morphine analogues and morphine antagonists. From Rauwolfia: Reserpine-structure eludication, structural modifications and uses. From vinca rosea: vincristine and vinblastine - structural modification, semisynthetic derivatives and uses.

UNIT - III

Steroids: Introduction, nomenclature, stereochemistry of steroids. Source and structure elucidation of cholesterol and diosgenin. Structures, structure modifications and therapeutic uses of steroidal anti-inflammatory agents and antifertility agents.

UNIT - IV

Polypeptides and proteins: introduction and general methods of separation, general methods of degradation and end group analysis, general methods of synthesis of peptides. Primary, secondary, tertiary and quaternary structure of proteins; chemistry of insulin.

UNIT - V

Compounds of medicinal Interest: Structure, structural modifications, mechanism of action and therapeutic uses of a) taxanes b) camptothecin c) artemisinin e) ginkgolides and f) gymnemic acids.

RECOMMENDED BOOKS:

• 1. Finar IL. Organic Chemistry-stereochemistry and the chemistry of natural products. 5th ed. vol 2. Delhi: Dorling Kindersley (India) Pvt. Ltd., 2006.
• 2. Morrison RT, Boyd RN. Organic Chemistry. 6th ed. Delhi: Pearson education Pvt. Ltd., 2003.
• 3. Pelletier SW. Alkaloids-chemical & biological perspectives. vol 1-15. London: Pergamon; 2001.
• 4. Steroids by Fischer & Fischer. th
• 5. Evans WC. Trease and evans pharmacognosy. 15 ed. Edinburgh: Saunders. 2004.
• 6. Ataur Rahman. Chemistry of natural products
• 7. Bhat SV, Nagasampagi BA, Sivakumar M. Chemistry of natural products. New Delhi: Narosa Publishing House; 2005. R19 M.PHARM PHARMACEUTICAL CHEMISTRY
• 8. Agrawal OP. Organic chemistry-natural products. 30th ed. vol 1-2. Meerut: Goel Publishing House; 2006.
• 9. Wallis TE. Textbook of pharmacognosy. 5th ed. New Delhi: CBS Publishers & Distributors; 2002.
• 10. Abraham DJ, editor. Burger’s medicinal chemistry and drug discovery. 6th ed. vol 1-6, Singapore: John Wiley & Sons, 2007. th
• 11. Lemke TL, Williams DA, Roche VF, Zito SW. Foye’s principles of medicinal chemistry. 6 ed. New Delhi: Wolters Kluwer/ Lippincott Williams & Wilkins. 2008.
• 12. Block JH, Beale JM, editor. Wilson and Gisvold’s textbook of organic medicinal and pharmaceutical chemistry. 11th ed. Baltimore: Lippincott Williams & Wilkins; 2004.
• 13. Jerry M. Advanced organic chemistry-reactions, mechanisms, and structure. 4th ed. Kundli: Replika Press Pvt. Ltd; 2003.
• 14. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s Illustrated biochemistry. 26th ed. New Delhi: Mc Graw Hill, 2003.
• 15. Rama Rao AVSS. A text book of biochemistry. 9th ed. Delhi: Rajkamal electric press, 2004.
• 16. Remington: The science and practice of pharmacy. 21st ed., vol. I & II, Lippincatt Willams & Wilkings, New Delhi, 2005. R19 M.PHARM PHARMACEUTICAL CHEMISTRY M.Pharm I Year I Sem (Pharmaceutical Chemistry)