JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

This course is designed to impart knowledge and skills necessary for contribution to quality use of medicines. Chapters dealt cover briefly pathophysiology and mostly therapeutics of various diseases. This will enable the student to understand the pathophysiology of common diseases and their management.

Course Outcome

At completion of this subject it is expected that students will be able to

understand –

• the pathophysiology of selected disease states and the rationale for drug therapy;
• the controversies in drug therapy;
• the importance of preparation of individualised therapeutic plans based on diagnosis;
• needs to identify the patient-specific parameters relevant in initiating drug therapy, and monitoring therapy (including alternatives, time-course of clinical and laboratory indices of therapeutic response and adverse effects);
• summarize the therapeutic approach to management of these diseases including reference to the latest available evidence;
• Therapy (including alternatives, time-course of clinical and laboratory indices of therapeutic response and adverse effects).
• Pathophysiology and applied Pharmacotherapeutics of diseases associated with following system/diseases with of special reference to the drug of choice.

UNIT - I

Principles of Pharacokinetics

• 1. Revision of basic concepts.
• 2. Clinical Pharmacokinetics.
• a. Dose – response in man
• b. Influence of renal and hepatic disease on Pharmacokinetics
• c. Therapeutics drug monitoring & individualization of drug therapy
• d. Population Pharmacokinetics.

UNIT - II

Adverse Drug Reactions, Drug Interactions, ADR monitoring & Pharmacovigilance.

UNIT - III

Pathophysiology and drug therapy of the following disorders. Schizophrenia, anxiety, depression, epilepsy, Parkinson’s, alzheimer’s diseases, migraine, hypertension, angina pectoris, arrhythmias, atherosclerosis, myocardial infaraction.

UNIT - IV

Pathophysiology and drug therapy of the following disorders. TB, leprosy, leukemia, solid tumors, lymphomas, psoriasis, respiratory, urinary, g.i. tract infections, endocarditis, fungal and HIV infection, rheumatoid arthritis, glaucoma, menstrual disorders, menopause.

R19 M.PHARM PHARMACOLOGY

UNIT - V

Drug therapy in

• a) Geriatrics
• b) Pediatrics
• c) Pregnancy & Lactation.
• d) Renal & hepatic insufficiency

REFERENCES:

• 1. Clinical Pharmacy and Therapeutics - Roger and Walker, Churchill Livingstone publication.
• 2. Pharmacotherapy: A Pathophysiologic approach - Joseph T. Dipiro et al. Appleton & Lange.
• 3. Pathologic basis of disease - Robins SL, W.B. Saunders publication.
• 4. Pathology and therapeutics for Pharmacists: A Basis for Clinical Pharmacy Practice - Green and Harris, Chapman and Hall publication.
• 5. Clinical Pharmacy and Therapeutics - Eric T. Herfindal, Williams and Wilkins Publication.
• 6. Applied Therapeutics: The clinical Use of Drugs. Lloyd Young and Koda-Kimble MA
• 7. Avery’s Drug Treatment, 4th Edn, 1997, Adis International Limited.
• 8. Relevant review articles from recent medical and pharmaceutical literature.
• 9. Pharmacotherapy: A Pathophysiologic approach - Joseph T. Dipiro et al. Appleton & Lange
• 10. Clinical Pharmacy and Therapeutics - Eric T. Herfindal, Williams and Wilkins Publication
• 11. Applied Therapeutics: The clinical Use of Drugs. Lloyd Young and Koda-Kimble MA R19 M.PHARM PHARMACOLOGY M.Pharm I Year I Sem (Pharmacology)