JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

Helps the students to get exposed to natural product drug discovery and to perform

quantitative and qualitative evaluation of herbal extracts. To understand the chemistry of important phyto consitituents of different categories.

Course Outcome

On the basis of chemistry data of phytoconstituents students will acquire knowledge

on various types of phytoconstituents present in the plants.

UNIT - I

Biosynthetic pathways and Radio tracing techniques: containing drugs:

• a) Methods of Biogenetic Investigations, detailed study of isotropic tracer techniques.
• b) Study of Biosynthetic pathways of of following phyto-pharmaceuticals: Atropine, Morphine, Cardiac glycosides and Flavonoids.

UNIT - II

Drug discovery and development: Approaches to discovery and development of natural products as potential new drugs. Sourcing and archiving Natural products for discovery, evaluating natural products for therapeutic properties, Identifying the biologically active Natural products, the lead structure selection process and Optimization with suitable examples from the following source: artemesin, andrographolides.

UNIT - III

• a) Extraction/Isolation methods for specific Phytochemical groups, Choice of solvents and Interfering compounds for general Isolation and purification of desired phytoconstituents.
• b) Recent sophisticated extraction techniques like: Super critical fluid extraction and Ultra-sonic extraction. Separation of phytoconstituents by Vacuum and Flash column chromatography.

UNIT - IV

Sources, Chemical structure, Identification tests, mechanism of action SAR, uses of the following phyto- pharmaceuticals:

• a) Atropine, caffeine, Morphine and brief account on its derivatives and analogues
• b) Camptothecin, Digoxin
• c) Taxol, Podophyllotoxin

UNIT - V

• a. Natural colorants: Biological Source, colouring principles, chemical nature and usage of the following Annatto, Cochineal, Caramel, Henna, Indigo, Madder, Saffron, Turmeric
• b. Flavours and Perfumes: Sandal wood oil, Orange oil, Lemon oil, Palmarosa oil, Geranium oil.

Reference books

• 1. Phytochemical methods of chemical analysis by Harbone
• 2. Modern methods of plant analysis- peach & M.V. Tracey Vol. 1 to VII
• 3. Pharmacognosy & Phytochemistry of medical plants by Jean Brunton
• 4. Thin layer chromatography by Stahl
• 5. Chemistry of natural products by Atur Rahman
• 6. Comprehensive Medicinal Chemistry, Vol 1-6, Elsevier Publication
• 7. Medicinal Chemistry Drug Discovery by Donald J, Abrahm,
• 8. Plant drug analysis by Wagner R19 M.PHARM PHARMACEUTICAL ANALYSIS
• 9. Clarke’s isolation & identification of drugs by AC Mottal
• 10. Chromatography of Alkaloids by Varpoorte Swendson
• 11. Jenkins Quantitative pharmaceutical chemistry by AN Kenwell
• 12. Standardization of botanicals by V. Rajpal Vol 1 & 2
• 13. Medicinal chemistry and drug discovery by Burger’s
• 14. Foye’s Principles of medicinal chemistry.
• 15. Pharmacognosy and phytochemistry by Biren seth
• 16. Herbal Perfumes and cosmetics by Panda
• 17. Herbal Drug Technology by SS Agarwal
• 18. Pharmacognosy and Phytochemistry by VD Rangari.
• 19. Textbook of Pharmacognosy by G.E. Trease, W.C.Evans, ELBS R19 M.PHARM PHARMACEUTICAL ANALYSIS M.Pharm I Year I Sem (Pharmaceutical Analysis)