JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

The students will acquire the knowledge about the various aspects of X-Ray

diffraction methods, all types of IR methods, particle sizing methods, also DSC, DTA, TGA etc

Course Outcome

By the completion of topics the students will come out with the thorough knowledge

of various spectral aspects of X-Ray, IR, SEM, ORD etc which help them in further projects works and also industrial opportunities.

UNIT - I

X-Ray diffraction methods: Origin of X-rays, basic aspects of crystals, X-ray crystallography, miller indices, rotating crystal techniques, single crystal diffraction, power diffraction, structural elucidation and applications.

UNIT - II

• a) FT-NIR: Principle (overtones, combinations, fermi resonance, interferences etc.), instrumentation (dispersion spectrometer and FT-NIR), advantage and disadvantage, qualitative and quantitative applications, including PAT and non-destructive analysis.
• b) ATR: Principle (total internal reflection, evanescent wave, etc.), instrumentation (ATR crystal, IR beam), advantages and disadvantages, pharmaceutical applications.

UNIT - III

ELECTROMETRIC TECHNIQUES: Principle, instrumentation and applications of Potentiometer, Amperometer, Conductometer and Polarography.

UNIT - IV

• a) Spectroflourimetry: Theory of Fluorescence, Factors affecting fluorescence (Characteristics of drugs that can be analysed by flourimetry), Quenchers, Instrumentation and Applications of fluorescence spectrophotometer.
• b) Flame emission spectroscopy and Atomic absorption spectroscopy: Principle, Instrumentation, Interferences and applications.

UNIT - V

FT-Raman: Principle (absorption, diffraction, scattering and emission of wave, molecular interaction), instrumentation (Dispersive Raman, FT-Raman), advantage and disadvantage, pharmaceutical applications including detection of counterfeit

REFERENCES:

• 1. Instrumental Methods of Chemical Analysis by B.K Sharma
• 2. Organic spectroscopy by Y.R Sharma
• 3. A Text book of Pharmaceutical Analysis by Kerrenth A. Connors
• 4. Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
• 5. Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
• 6. Organic Chemistry by I. L. Finar
• 7. Organic spectroscopy by William Kemp
• 8. Quantitative Analysis of Drugs by D. C. Garrett
• 9. Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
• 10. Spectrophotometric identification of Organic Compounds by Silverstein
• 11. HPTLC by P.D. Seth
• 12. Spectroscopy by Donald L Pavia, Gary M Lampman, George S Kriz, James A Vyvyan R19 M.PHARM PHARMACEUTICAL CHEMISTRY M.Pharm I Year I Sem (Pharmaceutical Chemistry)