JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The students shall apply the pharmacokinetic and pharmacodynamic principles

in the design of CDDS. They also apply the design, evaluation and applications related to oral, parenteral, transdermal, implants, bioadhesives and targeted drug delivery systems.

Course Outcomes

Students will select the drugs for CDDS design of the formulation fabrication of

systems of above drug delivery systems with relevant applications.

UNIT - I

Fundamentals of controlled drug delivery systems, pharmacokinetic and pharmacodynamic basis of controlled drug delivery. Design, fabrication, evaluation and applications of the following controlled releasing systems

• a. Controlled release oral drug delivery systems
• b. Parenteral controlled release drug delivery systems

UNIT - II

Design, fabrication, evaluation and applications of the following

• a. Implantable Therapeutic systems
• b. Transdermal delivery systems
• c. Ocular and Intrauterine delivery systems
• d. Vaccine delivery: Delivery systems used to promote uptake, absorption enhancers, oral immunization, controlled release microparticles form vaccine development

UNIT - III

Biochemical and molecular biology approaches to controlled drug delivery of

• a. Bioadhesive drug delivery systems
• b. Nasal drug delivery systems
• c. Drug delivery to Colon

UNIT - IV

Biochemical and molecular biology approaches to control drug delivery of

• a. Liposomes
• b. Niosomes
• c. Microspheres
• d. Nanoparticles
• e. Resealed erythrocytes

UNIT - V

Drug targeting to particular organs

• a. Delivery to lungs
• b. Delivery to the brain and problems involved
• c. Drug targeting in neoplasams

TEXT BOOKS:

• 1. Novel Drug Delivery System by Yie W. Chien.
• 2. Controlled Drug Delivery by Joseph R. Robinson and Vincent H. L. Lee.
• 3. Controlled and Novel Drug Delivery Systems by N. K. Jain.
• 4. Targeted and Controlled Drug Delivery (Novel carrier systems) by S. P. Vyas and Khar.
• 5. Modern Pharmaceutics by Gilbert S. Banker and Christopher T. Rhodes.
• 6. Advances in Drug Delivery, Vol 1, 2, 3 by Y. Madhusudan Rao, A.V. Jithan
• 7. Oral Drug Delivery Technology, 2nd ed, by AukunuruJithan M.Pharm I Year II Sem (Industrial Pharmacy)