JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
ADVANCED ORGANIC CHEMISTRY – I LAB
M.Pharmacy I Year I Semester (R22)
List of Experiments: (Minimum of 10 experiments shall be conducted)
1. Synthesis and characterization of the following drugs:
a. Benzanilide by Beckmann rearrangement
b. 4-Benzylidene-2-methyloxazol-5-one (or) azalactone
c. N-(m-Nitrobenzyl) aniline from m-nitrobenzaldehyde
d. 2, 3-Diphenyl quinoxaline
e. 1H-Indole-3-carboxaldehyde
f. 3, 4-Dihydropyrimidin-2(1H)-one from benzaldehyde, ethyl acetoacetate and urea in presnce of CaCl2 (catalyst).
g. Schiff base by microwave irradiation
h. Cinnamic acid by Perkin reaction
i. β-Ddimethylaminopropiophenone hydrochloride (Mannich base)
j. 2-Phenyl indole
k. Dimedone (5,5-dimethyl cyclohexane-1,3-dione)
l. 3-Bromo cyclohexene from cyclohexene using NBS.
m. p-Amino benzyl alcohol from p-amino benzaldehyde using sodium borohydride.
n. Cyclohexane-2,5-dicarboxylic acid from benzoic acid (hydrogenation).
2. Any other relevant experiments based on theory.
REFERENCE BOOKS:
1. Roth H J, Kleemann A. Pharmaceutical Chemistry. Vol-I. Drug synthesis. New York: Ellis Horwood Limited; 1988.
2. Mann FG, Saunders BC. Practical organic chemistry. 4th ed. New Delhi: Orient Longman; 2005.
3. Furniss BS, Hanaford AJ, Smith PWG, Tatchell AR. Vogel’s textbook of practical organic chemistry. 5th ed. Singapore: Longman Singapore Publishers P Ltd; 1989.
4. Vogel A. Elementary practical organic chemistry. Part 1: Small scale preparations. 2nd ed. New Delhi: CBS publishers and distributors; 2004. th
5. Bansal RK. Laboratory manual of organic chemistry. 4 ed. New Delhi: New Age International (P) limited; 2005.
6. Kar A. Advanced Practical Medicinal Chemistry. New Delhi: New Age International (P) limited; 2006. M.Pharm I Year I Sem (Pharmaceutical Chemistry)
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