JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

The subject is designed to strengthen the basic knowledge in the field of

pharmacology and to impart recent advances in the drugs used for the treatment of various diseases. In addition, this subject helps the students to understand the concepts of drug action and mechanisms involved.

Course Outcome

Upon completion of the course the student shall be able to:

• Discuss the pathophysiology and pharmacotherapy of certain diseases
• Explain the mechanism of drug actions at cellular and molecular level
• Understand the adverse effects, contraindications and clinical uses of drugs used in treatment of diseases

UNIT - I

General Pharmacology:

• a. Pharmacokinetics: The dynamics of drug absorption, distribution, biotransformation and elimination. Concepts of linear and non-linear compartment models. Significance of Protein binding.
• b. Pharmacodynamics: Mechanism of drug action and the relationship between drug concentration and effect. Receptors, structural and functional families of receptors quantitation of drug receptors interaction and elicited effects.

UNIT - II

Neurotransmission

• a. General aspects and steps involved in neurotransmission.
• b. Neurohumoral transmission in autonomic nervous system (Detailed study about neurotransmitters- Adrenaline and Acetylcholine).
• c. Neurohumoral transmission in central nervous system (Detailed study about neurotransmitters- histamine, serotonin, dopamine, GABA, glutamate and glycine].
• d. Non-adrenergic non-cholinergic transmission (NANC). Cotransmission Systemic Pharmacology A detailed study on pathophysiology of diseases, mechanism of action, pharmacology and toxicology of existing as well as novel drugs used in the following systems Autonomic Pharmacology Parasympathomimetics and lytics, sympathomimetics and lytics, agents affecting neuromuscular junction

UNIT - III

Central nervous system Pharmacology General and local anesthetics Sedatives and hypnotics, drugs used to treat anxiety. Depression, psychosis, mania, epilepsy, neurodegenerative diseases. Narcotic and non-narcotic analgesics.

UNIT - IV

Cardiovascular Pharmacology Diuretics, antihypertensives, antiischemics, anti- arrhythmics, drugs for heart failure and hyperlipidemia. Hematinics, coagulants, anticoagulants, fibrinolytics and antiplatelet drugs.

UNIT - V

Autacoid Pharmacology The physiological and pathological role of Histamine, Serotonin, Kinins Prostaglandins Opioid autacoids. Pharmacology of antihistamines, 5HT antagonists.

REFERENCE BOOKS:

• 1. The Pharmacological Basis of Therapeutics, Goodman and Gillman‘s
• 2. Principles of Pharmacology. The Pathophysiologic basis of drug Therapyby David E Golan, Armen H, Tashjian Jr, EhrinJ, Armstrong, April W, Armstrong, Wolters, Kluwer-Lippincott Williams & Wilkins Publishers.
• 3. Basic and Clinical Pharmacology by B. G Katzung
• 4. Hand book of Clinical Pharmacokinetics by Gibaldi and Prescott.
• 5. Applied biopharmaceutics and Pharmacokinetics by Leon Shargel and Andrew B. C. Yu.
• 6. Graham Smith. Oxford textbook of Clinical Pharmacology.
• 7. Dipiro Pharmacology, Pathophysiological approach.
• 8. Advnced Pharmacology by Bikash Medhi. M.Pharm I Year I Sem (Pharmacology)