M.Pharmacy I Year I Semester (R22)
the students shall know about particle science, polymer science and its use in
pharmaceutical dosage forms. They also know the compression and consolidation parameters for powders and granules. Students also know about the rheology, disperse systems, dissolution and solubility parameters for dosage forms.
The students will know particle size analysis method, solid dispersion, physics of
tablets, polymer classification and its applications, student will also know the stability calculations, shelf life calculations and accelerated stability studies. They also know the rheology, absorption related to liquids and semi-solid dosage forms. They also know the factors affecting the dissolution and solubility in related to invitro/invivo correlations.
Polymer science: Classification, properties and characterization of polymers, phase separation, polymers in solid state, preparation of polymer solution, application of polymers in pharmaceutical formulations. Mechanism of biodegradation of biodegradable polymers including controlled drug delivery systems, Mucoadhesive, Hydrodynamically balanced and Transdermal Systems.
Physics of tablet compression: Basic principles of interactions, compression and consolidation, compression and consolidation under high loads, effect of friction, distribution of forces in compaction, force volume relationships, Heckel plots, compaction profiles, energy involved in compaction, Measurement of compression with strain gauges, compression pressure-QA parameters.
Kinetics and drug stability: Stability calculations, rate equations, complex order kinetics, Factors influencing stability, strategy of stability testing, method of stabilization, method of accelerated stability testing in dosage forms, temperature and humidity control, physical stability testing of pharmaceutical products. Photodecomposition, Method, solid state decomposition.
Visco elasticity: Theoretical consideration, instrumentation, rheological properties of disperse systems and semisolids. Oscillatory testing, Creep measurement. Characterization of API and excipients: Differential Scanning Calorimetry: Principle, thermal transitions, advantages, disadvantages, instrumentation, applications and interpretations X Ray Diffraction methods: Origin of x-rays, principle, advantages, disadvantages, instrumentation, applications and interpretations.
Dissolution and solubility: Solubility and solubilization of nonelectrolytes, solubilization by the use of surfactants, co solvents, Complexation, drug derivatization and solid state manipulation, Mechanisms of Drug release - dissolution, diffusion (Matrix and Reservoir) and swelling controlled (Peppas Model) and dissolution equipment.
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