JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Overview

List of experiments

Handling of laboratory animals.

• 1. Various routes of drug administration.
• 2. Study of techniques of blood sampling, anesthesia and euthanasia of experimental animals.
• 3. To record the dose response curve of Ach using isolated ileum/rectus abdominis muscle preparation.
• 4. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by interpolation method.
• 5. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by three point method.
• 6. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by four point method.
• 7. Estimation of pA2 value on isolated tissues
• 8. Bioassay of 5-HT using rat fundus strip
• 9. Bioassay of oxytocin using rat uterus
• 10. Bioassay of Acetylcholine using isolated tissue of coccyx muscles by three-point/ four-point method.
• 11. Bioassay of Adrenaline/ Acetylcholine using isolated blood vessels by three-point/ four- point method.

REFERENCE BOOKS:

• 1. CPCSEA, OECD, ICH, USFDA, Schedule Y, EPA guidelines,
• 2. Fundamentals of experimental Pharmacology by M. N. Ghosh
• 3. Handbook of Experimental Pharmacology by S.K. Kulkarni.
• 4. Drug discovery and Evaluation by Vogel H.G.
• 5. Practical Manual of Experimental and Clinical Pharmacology by Bikash Medhi (Author), Ajay Prakash (Author) Jaypee brothers’ medical publishers Pvt. Ltd
• 6. A practical book of Pharmacology by Ramesh Alluri
• 7. Practical Manual of Experimental and Clinical Pharmacology by Bikash Medhi (Author), Ajay Prakash (Author) Jaypee brothers’ medical publishers Pvt. Ltd. M.Pharm I Year I Sem (Pharmacology) CLINICAL PHARMACOLOGY AND PHARMACOTHERAPEUTICS LAB (Lab – II) The students are required to be collect Prescriptions and of clinical details of different patients for their exposure with therapeutic management and other clinical aspects. They are expected to have experience and do a case presentation in the following clinical conditions. The students have to make at least 5 case presentations covering most common diseases. The student should also submit a record of the cases presented. The list of clinical cases presented should include follow-up of the clinical cases mentioned below from the day of admission till discharge and presented in the SOAP (Subjective, Objective, Assessment and Plan) format. I. The cases may be selected from the following diseases:
• 1. Neurology& Psychiatry
• 2. Oncology
• 3. Infectious Diseases & Immunology
• 4. Gynecologic & Obstetric Disorders/ Ophthalmology
• 5. Cardiology
• 6. Dermatology
• 7. Endocrinology II. Rational use of medicines in special population (three) III. Calculation of Bioavailability and Bioequivalence from the given data (two) IV. Interpretation of Therapeutic Drug Monitoring reports of a given patient (three) V. Calculation of various Pharmacoeconomic outcome analysis for the given data (two) Assignments The students are required to submit a minimum of three written assignments (1500 to 2000 words) selected from the topics on different disease conditions given to them. The students are required to discuss both the clinical and therapeutic aspects in the same. M.Pharm I Year II Sem (Pharmacology)