JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

This course is designed to impart basic knowledge about biopharmaceutics, drug

ADME process, kinetic modeling and distribution of drug. T

Course Outcome

Upon completion of this course it is expected that students shall be able to:

Understand the organizational structure of hospital pharmacy Understand drug policy and drug committees Know about procurement & drug distribution practices Know the admixtures of radiopharmaceuticals Understand the community pharmacy management Know about value added services in community pharmacies

UNIT - I

Introduction to Biopharmaceutics I. Absorption of drugs from gastrointestinal tract. II. Drug Distribution. III. Drug Elimination.

UNIT - II

Introduction to Pharmacokinetics.

• a. Mathematical model
• b. Drug levels in blood.
• c. Pharmacokinetic model
• d. Compartment models
• e. Pharmacokinetic study.

UNIT - III

One compartment and Multicompartment models.

• a. Intravenous Injection (Bolus)
• b. Intravenous infusion.
• c. Two compartment open model.
• d. IV bolus, IV infusion and oral administration

UNIT - IV

Nonlinear Pharmacokinetics.

• a. Introduction
• b. Factors causing Non-linearity.
• c. Michaelis-menton method of estimating parameters.

UNIT - V

Bioavailability and Bioequivalence.

• a. Introduction.
• b. Bioavailability study protocol.
• c. Methods of Assessment of Bioavailability

TEXT BOOKS:

• 1. Biopharmaceutics and Clinical Pharmacokinetics by Milo Gibaldi.
• 2. Learn Shargel and ABC yu, Applied Biopharmacokinetics and
• 3. Biopharmaceutics and Pharmacokinetics by C.V.S. Subrahmanyam, Vallabh Prakashan.2010.
• 4. Basic biopharmaceutics, Sulnil S. Jambhekar and Philip J Brean.
• 5. Text book of Biopharmaceutics and Clinical Pharmacokinetics by Niazi Sarfaraz
• 6. Bio-Pharmaceutics and Pharmacokinetics by V. Venkateshwarlu. M. Pharm I Year II Sem (PHARMACY PRACTICE)