JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

In the current scenario of accidental, homicidal and suicidal excessive

consumption of drugs, pesticides, heavy metals and other poisonings, this elective helps the students to acquire the required knowledge and skills in the management of poisoning.

Course Outcome

At the end of the course the student is equipped with handling the first aid,

elimination enhancement and treatment of poisoning and supportive care in poisoning due to

• Pesticides
• Drug over usage
• Heavy metals
• Radiation
• Snakes and anthropod bites
• Food poisoning The student also gains knowledge in substance abuse and treatment of drug dependence.

UNIT - I

General principles involved in the management of poisoning, antidotes and the clinical applications.

UNIT - II

Supportive care in clinical toxicology. Gut decontamination, elimination enhancement and toxicokinetics.

UNIT - III

Clinical symptoms and management of acute poisoning with the following agents –

• a) Pesticide poisoning: organophosphorus compounds, carbamates, organochlorines, pyrethroids.
• b) Opiates overdose. c) Antidepressants d) Barbiturates and benzodiazepines. e) Alcohol: ethanol, methanol. f) Paracetamol and salicylates. g) Non-steroidal anti-inflammatory drugs. h) Hydrocarbons: Petroleum products and PEG. i) Caustics: inorganic acids and alkalis. j) Radiation poisoning

UNIT - IV

Clinical symptoms and management of chronic poisoning with the following agents –

• a) Heavy metals: Arsenic, lead, mercury, iron, copper b) Venomous snake bites: Families of venomous snakes, clinical effects of venoms, general management as first aid, early manifestations, complications and snake bite injuries. c) Plants poisoning. Mushrooms, Mycotoxins. d) Food poisonings e) Envenomations – Arthropod bites and stings.

UNIT - V

Substance Abuse: Signs and symptoms of substance abuse and treatment of dependence

• a) CNS stimulants: amphetamine
• b) Opioids
• c) CNS depressants
• d) Hallucinogens: LSD
• e) Cannabis group
• f) Tobacco

REFERENCE BOOKS:

• 1. Matthew j ellenhorn. Ellenhorns medical toxicology – diagnosis and treatment of poisoning. Second edition. Williams and willkins publication, london b.
• 2. 2. V V Pillay. Handbook of forensic medicine and toxicology. Thirteenth edition 2003 paras publication, Hyderabad M. Pharm I Year I Sem (PHARMACY PRACTICE)