JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objectives

The students will expose to characteristic features of various phytochemicals as

nutraceuticals in various diseased conditions and also know the role of antioxidant in free radical induced disease conditions and will expose to various food laws and regulations.

Course Outcomes

Helps the student to understand the importance of Nutraceuticals in various

common problems with the concept of free radicals

UNIT - I

• a. Definitions of Functional foods, Nutraceuticals and Dietary supplements. Classification of Nutraceuticals, Health problems and diseases that can be prevented or cured by Nutraceuticals i.e. weight control, diabetes, cancer etc.
• b. Source, Name of marker compounds and their chemical nature, Medicinal uses and health benefits of following used as nutraceuticals/functional foods: Spirulina, Soyabean, Ginseng, Garlic, Broccoli, Gingko, Flaxseeds

UNIT - II

Phytochemicals as nutraceuticals: Occurrence and characteristic features (chemical nature medicinal benefits) of following

• a) Carotenoids- α and β-Carotene, Lycopene, Xanthophylls, lutein
• b) Sulfides: Diallylsulfides, Allyltrisulfide.
• c) Polyphenolics: Reservetrol
• d) Flavonoids- Rutin , Naringin, Quercitin, Anthocyanidins, catechins, Flavones
• e) Prebiotates / Probiotics.: Fructo oligosaccharides, Lactobacillum
• f) Phytoestrogens: Isoflavones, daidzein, Geebustin, lignans
• g) Tocopherols

UNIT - III

• a. Introduction to free radicals: Free radicals, reactive oxygen species, production of free radicals in cells, damaging reactions of free radicals on lipids, proteins, Carbohydrates, nucleic acids.
• b. Measurement of free radicals: Lipid peroxidation products, lipid hydroperoxide, malondialdehyde.

UNIT - IV

• a. Free radicals in Diabetes mellitus, Inflammation, Ischemic reperfusion injury, Cancer, Atherosclerosis, Free radicals in brain metabolism and pathology, kidney damage, muscle damage. Free radicals involvement in other disorders. Free radicals theory of ageing.
• b. Antioxidants: Endogenous antioxidants – enzymatic and nonenzymatic antioxidant defence, Superoxide dismutase, catalase, Glutathione peroxidase, Glutathione Vitamin C, Vitamin E, α- Lipoic acid, melatonin Synthetic antioxidants: Butylatedhydroxy Toluene, Butylatedhydroxy Anisole.

UNIT - V

Food Laws and Regulations; FDA, FPO, MPO, AGMARK. HACCP and GMPs on Food Safety. Adulteration of foods. Regulations and Claims – Current Products: Label Claims, Nutrient Content Claims, Health Claims, Dietary Supplements Claims

REFERENCE BOOKS:

• 1. Dietetics by Sri Lakshmi
• 2. Role of dietary fibres and nutraceuticals in preventing diseases by K. T. Agusti and P. Faizal: BS Publication.
• 3. Advanced Nutritional Therapies by Cooper. K.A., (1996).
• 4. The Food Pharmacy by Jean Carper, Simon & Schuster, UK Ltd., (1988).
• 5. Prescription for Nutritional Healing by James F.Balch and Phyllis A. Balch 2nd Edn., Avery Publishing Group, NY (1997).
• 6. G. Gibson and C. Williams Editors 2000 Functional foods Woodhead Publ. Co. London.
• 7. Goldberg, I. Functional Foods. 1994. Chapman and Hall, New York.
• 8. Labuza, T.P. 2000 Functional Foods and Dietary Supplements: Safety, Good Manufacturing Practice (GMPs) and Shelf Life Testing in Essentials of Functional Foods M. K. Sachmidl and T.P. Labuza eds. Aspen Press.
• 9. Handbook of Nutraceuticals and Functional Foods, Third Edition (Modern Nutrition)
• 10. Shils, ME, Olson, JA, Shike, M. 1994 Modern Nutrition in Health and Disease. Eighth edition. Lea and Febiger M.Pharm I Year II Sem (PHARMACY PRACTICE) PHARMACOTHERAPEUTICS - II LAB (Laboratory - III) The students are required to be posted to various clinical wards for their exposure with therapeutic management and other clinical aspects. They are expected to have experience and do a tutorial as well as case presentation in the following clinical conditions. The students have to make at least 10 case presentations covering most common diseases found in the hospital to which the college is attached. The student should also submit a record of the cases presented. The list of clinical cases presented should include follow-up of the clinical cases mentioned below from the day of admission till discharge and presented in the SOAP (Subjective, Objective, Assessment and Plan) format. I. The cases may be selected from the following diseases: 7. Neurology & Psychiatry 8. Oncology 9. Infectious Diseases & Immunology 10. Dermatology II. Rational use of medicines in special population admitted in above wards (three) III. Calculation of Bioavailability and Bioequivalence from the given data (two) IV. Interpretation of Therapeutic Drug Monitoring reports of a given patient of any of the above wards (three) V. Calculation of various Pharmacoeconomic outcome analysis for the given data from the above (two) ASSIGNMENTS: The students are required to submit a minimum of three written assignments (1500 to 2000 words) selected from the topics on different disease conditions given to them. The students are required to discuss both the clinical and therapeutic aspects in the same.

REFERENCE BOOKS:

• 1. Roger and Walker. Clinical Pharmacy and Therapeutics – Churchill Livingstone publication.
• 2. Joseph T. Dipiro et al. Pharmacotherapy: A Pathophysiologic Approach-Appleton & Lange
• 3. Robins SL. Pathologic basis of disease -W. B. Saunders publication
• 4. Eric T. Herfindal. Clinical Pharmacy and Therapeutics- Williams and Wilkins Publication
• 5. Lloyd Young and Koda-Kimble MA Applied Therapeutics: The clinical Use of Drugs- Lippincott Williams and Wilkins
• 6. Clinical Pharmacy and Pharmacotherapeutics by Ravi Shankar, Pharma med Press
• 7. Chisholm - Burns Wells Schwinghammer Malone and Joseph P Dipiro. Pharmacotherapy Principles and practice-– McGraw Hill Publication M.Pharm I Year II Sem (PHARMACY PRACTICE)