JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

In current methods of treatment which involves individualization of drug

therapy, the student should have sound knowledge in pharmacokinetics and the effects of changes in pharmacokinetic parameters on therapeutic efficacy of the drugs.

Course Outcomes

Upon completion of the subject student shall be able to (Know, do,

appreciate);

• Understand various pharmacokinetic parameters
• Influence of these parameters on efficacy of drugs
• Identify and resolve drug related problems;
• Pharmacogenetics

UNIT - I

Drug Absorption: Gastrointestinal, percutaneous, and rectal kinetics and factors affecting drug absorption. Absorption kinetics

UNIT - II

Drug Distribution: Plasma protein binding – factors affecting plasma protein binding – Tissue binding – transfer of drugs through biological barriers their therapeutic implication in drug action. Volume of distribution. Reaction of the body to foreign substances: Biotransformation of drugs, phase I and phase II metabolic reactions. Hepatic Clearance

UNIT - III

Elimination of drugs: Concept of renal clearance and excretion of drugs –biological half – life, area under curve.

UNIT - IV

Bioavailability of drug products: Bioavailability tests. Bioequivalence. Compartment models and relevant pharmacokinetic parameters.

UNIT - V

Pharmacogenetics: Inter racial and individual variability in drug metabolism.

REFERENCE BOOKS:

• 1. Shargel and Leon. Applied Biopharmaceutics and pharmacokinetics. Latest edition. Publisher: Prentice Hall, London.
• 2. Biopharmaceutics and Clinical Pharmacokinetics by, Milo Gibaldi b. Remington’s Pharmaceutical Sciences, By Mack Publishing Company, Pennsylvnia.
• 3. Pharmacokinetics: By Milo Glbaldi Donald, R. Mercel Dekker Inc.
• 4. Hand Book of Clinical Pharmacokinetics, By Milo Gibaldi and Laurie Prescott by ADIS Health Science Press.
• 5. Biopharmaceutics and Pharmacokinetics; By Robert F Notari f. Biopharmaceutics; By Swarbrick
• 6. Biopharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil B. Jaiswal, Vallabh Prakashan Pitampura, Delhi
• 7. Cilincal Pharmacokinetics, Concepts and Applications: By Malcolm Rowland and Thomas, N. Tozer, Lea and Febrger, Philadelphia, 1995.
• 8. Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing Company, Pennsylvania 1989.
• 9. Biopharmaceutics and Clinical Pharmacokinetics - An introduction 4th edition Revised and expanded by Robert F Notari Marcel Dekker Inn, New York and Basel, 1987.
• 10. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James, Roylan, Marcel Dekker Inc, New York 1996. M.Pharm I Year I Sem (Pharmacology)