JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

PHARMACOLOGICAL SCREENING METHODS AND TOXICOLOGY LAB

M.Pharmacy I Year II Semester (R22)

List of Experiments

Study of theory, principle, procedure involved, and interpretation of given results for the following experiments:

  • 1. Analgesic property of drug using analgesiometer.
  • 2. Anti-inflammatory effect of drugs using rat-paw edema method.
  • 3. Anticonvulsant activity of drugs using maximal electroshock and pentylenetetrazole methods.
  • 4. Antidepressant activity of drugs using pole climbing apparatus and pentobarbitone induced sleeping time methods.
  • 5. Locomotor activity evaluation of drugs using actophotometer and rotorod.
  • 6. Cardiotonic activity of drugs using isolated frog heart and mammalian heart preparations.
  • 7. Antidiabetic activity using rats / mice.n
  • 8. Hepatoprotective activity
  • 9. Anti ulcer activity
  • 10. Antioxidant activity
  • 11. Toxicity studies as per OECD guidelines.
  • 12. Functional observation battery tests (modified Irwin test)

REFERENCE BOOKS

  • 1. Screening Methods in Pharmacology, Robert A. Turner.
  • 2. Biological standardization by J. H. Burn D.J. Finney and I.G. Goodwin
  • 3. Screening methods in Pharmacology by Robert Turner. A
  • 4. Evaluation of drugs activities by Laurence and Bachrach
  • 5. Methods in Pharmacology by Arnold Schwartz.
  • 6. Fundamentals of experimental Pharmacology by M. N. Ghosh
  • 7. Pharmacological experiment on intact preparations by Churchill Livingstone
  • 8. Pharmacological screening methods and toxicology by A. Srinivasa Rao
  • 9. Experimental Pharmacology by R. K. Goyal.
  • 10. Preclinical evaluation of new drugs by S. K. Guta
  • 11. Handbook of Experimental Pharmacology, S K. Kulkarni
  • 12. Practical Pharmacology and Clinical Pharmacy, S K. Kulkarni, 3rd Edition. M.Pharm II Year I Sem (Pharmacology)

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