JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

Course Objective

This subject will provide the knowledge about the sourse, phytochemistry,

physiological activities of anticancer, CVS &Nervous systems and anti-inflammatory drugs from natural sources. This also gives information about isolation and characterization of phytoconstituents.

Course Outcome

Upon completion of the course, the student shall be able to,

• Explain the sourses of phytoconstituents
• able to know activities of different kind
• able to isolate and characterization constituents.
• Detect chemical nature by different spectra’s. Source, phytochemistry (isolation, identification, chemical nature), and physiological activities of following phytopharmaceuticals.

UNIT - I

• 1) Anticancer: Taxol, other taxanes, Camptothecin, vinblastine, Genistein, Etoposide

UNIT - II

• 2) Nervous system activities: Hypericin, Valepotriates, Gingkolides
• 3) CVS activities: Colenol, Streptokinase

UNIT - III

• 4) Anti-inflammatory: Curcuminoids, Guggulipids, Boswellic acid, Serratiopeptidase.

UNIT - IV

• 5) Miscellaneous: Silymarin, Artemisinin, Omega-3 fatty acids. Charantin and momordicosides, Resveretrol, Protamine sulphate, prostaglandins.

UNIT - V

Occurrence, isolation and characteristic features (Chemical nature, uses in pharmacy, medicinal and health benefits) of following.

• a) Carotenoids – i) α and β - Carotene ii) Xanthophyll (Lutein)
• b) Limonoids – i) d-Limonene ii) α – Terpineol
• c) Saponins – i) Shatavarins
• d) Flavonoids – i) Resveratrol ii) Rutin iii) Hesperidin iv) Naringin v) Quercetin
• e) Phenolic acids- Ellagic acid
• f) Tocotrienols and Tocopherols

TEXT BOOKS:

• 1. Pharmacognosy: Trease and Evans, Bailliere & Tindall, 14th edth.
• 2. Pharmacognosy: Kokate, Purohit, Gokhale, Nirali Prakashan, Pune, 15th edtn.
• 3. Biochemistry: Delvin
• 4. Alkaloids Edited by J.R.F. Manske
• 5. Various Research Journals on Natural products and therapeutics. M.Pharm (PHARMACY PRACTICE)