JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

UNIT - I

Introduction to Optical Fibers: Basic optical laws and definitions, optical fiber modes and configuration, single mode fibers, graded index fiber structure, fiber materials, attenuation, signal distortion in optical waveguides, pulse broadening in graded index waveguides.

UNIT - II

Optical Properties of Tissues: Tissue properties – refractive indices, scattering and absorption properties, light transport inside the tissue, light interactions with a strongly scattering tissue – continuous wave light, short light pulses, diffused photon density waves, Temperature rise and tissue damage – optothermal and opt acoustic effects. Fluorescence speckles.

UNIT - III

Instrumentation in Photonics: Instrumentation for absorption, scattering and emission measurement, excitation light sources – high pressure arc lamp, solid state LEDs, LASERs, optical filters, polarizer’s, solid state detectors, time resolved and phase resolved detectors

UNIT - IV

Biophotonic Diagnostics: Near IR spectroscopy for biological glucose analysis, flowcytometry – basic operation, optical response – applications – optical biosensors – principles, biorecognition, optical transduction – Bioimaging – cellular, tissue imaging and in vivo imaging. Introduction to Optical Coherence Tomography

UNIT - V

Biophotonic Therapy: Photodynamic therapy – basic principle, photo sensitizers, mechanism of photodynamic action, applications – Laser tissue welding, lasers in dermatology, neurosurgery, ophthalmology, urology.

TEXT BOOKS:

• 1. Keiser,” Optical Fiber Communication Systems”, McGraw Hill Ltd., 1983
• 2. Ed., Tuan Volume Dinh, “Biomedical Photonics Handbook”, CRC Press, 2003.
• 3. Leon Goldman, “The Biomedical Laser Technology and Clinical Applications”, Springer Verlag, 1981.

REFERENCE BOOKS:

• 1. Leon Goldman and R. James Rockwell, “Lasers in Medicine”, Gordan & Breach, Science Publishers Inc, 1971
• 2. Koebmer K R, "Lasers in Medicine", John Wiley & Sons, 1980
• 3. Paras N Prasad, “Introduction to Biomedical Photonics”, John Wiley. 2003 M. TECH. I YEAR II SEMESTER BIOMEDICAL SIGNAL PROCESSING AND INSTRUMENTATION