JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD

UNIT - I

Physiological Systems with feedback: Modeling of physiological systems, model based noise reduction and feature extraction, Physiological control systems analysis. Differences between engineering and physiological control systems, Mathematical modeling, linear models of physiological systems, distributed parameter and lumped parameter models

UNIT - II

Static Analysis of Physiological Systems: Determination of steady state operating point, Steady state, analysis, Regulation of cardiac output, Chemical regulation of ventilation. Time domain analysis of linear control systems. Transient response analysis- dynamics of neuromuscular reflex motion, Frequency domain analysis of linear control systems, frequency response of circulatory control and glucose insulin regulation.

UNIT - III

Relative Stability: Stability analysis of pupilary light reflex, model of Cheyne-Stokes breathing, Identification of physiological control systems, parametric estimation, identification of closed loop, system, optimization of physiological control, single parametric optimization, constrained optimization, and adaptive control of physiological variables.

UNIT - IV

Modeling the Nerve Action Potential: Voltage clamp experiment and its interpretation, model for the strength duration curve, modeling skeletal muscle contraction, cross bridge theory of muscle contraction, linear model of muscle contraction, applications of skeletal muscle contraction, modeling myoelectric activity

UNIT - V

System Identification in Physiology: Modeling of sensory receptors and pupil control system. Modeling cardiovascular system, Modeling blood flow, systemic blood flow and coronary circulation. Behavior of the immune system, linearized model of immune response to disease.

TEXT BOOKS:

• 1. Michael C.K. Khoo, “Physiological Control Systems-Analysis Simulation and Estimation”, IEEE Press Series in Biomedical Engineering, 2000.
• 2. Suresh R. Devasahayam, “Signals and Systems in Biomedical Engineering-Signal Processing and Physiological Systems Modeling”, Kluwer Academic/Plenum Publishers, 2000.

REFERENCE BOOKS:

• 1. Milsum John H. Biological, “Control System Analysis”, Mc Graw Hill, 1996. M. TECH. I Year II SEMESTER BIOMEDICAL SIGNAL PROCESSING AND INSTRUMENTATION