JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy II BIOCHEMISTRY Previous Question Paper (April/May - 2023 - R17)
Question paper consists of Part A, Part B. Part A is compulsory, which carries 25 marks. In Part A, answer all questions. In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Discuss the hormonal regulation of blood glucose.
Answer
Blood glucose is primarily regulated by the antagonistic hormones insulin, which lowers blood glucose by promoting cellular uptake and glycogenesis, and glucagon, which raises blood glucose by stimulating glycogenolysis and gluconeogenesis in the liver.
What is ETC? Explain its mechanism.
Answer
The Electron Transport Chain (ETC) is a series of protein complexes located in the inner mitochondrial membrane that transfer electrons from NADH and FADH2 to oxygen. This electron flow creates a proton gradient across the membrane, which drives ATP synthesis via oxidative phosphorylation.
Discuss the formation of ketone bodies.
Answer
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Explain the disorders of lipid metabolism.
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Discuss the organization of mammalian genome.
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Explain the process of protein synthesis.
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Write the classification and biological significance of amino acids.
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What is redox potential?
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What is isoenzyme? Explain its biochemical functions.
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Write the properties and nomenclature of enzymes.
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Part B
What is glycolysis? Explain the pathway and energetics.
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What is gluconeogenesis? Explain the pathway and significance.
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Discuss the biological significance of cholesterol and conversion of cholesterol into bile acids.
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Explain the Denovo synthesis of palmitic acid.
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Elaborate the biosynthesis of purine nucleotides.
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Write the structure and functions of DNA and RNA.
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Discuss the relationship between free energy, enthalpy and entropy.
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Write the classification, chemical nature and biological role of nucleic acids.
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Explain the biological significance and structure of cyclic AMP.
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Explain the Michaelis and Lineweaver burke plot with examples.
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Therapeutic and diagnostic applications of enzymes.
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Allosteric enzyme regulations.
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