JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy II BIOCHEMISTRY Previous Question Paper (May-2019 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks.
Part A
Write a note on glucose tolerance test
Answer
The Glucose Tolerance Test (GTT) is a diagnostic procedure used to assess the body's ability to metabolize glucose. It involves measuring blood glucose levels at intervals after the oral administration of a standard dose of glucose (usually 75g) to identify impaired glucose tolerance or diabetes mellitus.
Mention the specific enzymes necessary for the gluconeogenesis.
Answer
The key bypass enzymes required for gluconeogenesis are:
- Pyruvate carboxylase and Phosphoenolpyruvate carboxykinase (PEPCK)
- Fructose-1,6-bisphosphatase
- Glucose-6-phosphatase
Describe the fate of lipids in our body.
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Write notes on hyperuricemia and gout
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Explain about RNA synthesis or transcription.
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Write a note on energy rich compounds
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Explain the biological significance of amino acids.
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Explain Biological role of lipids
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Explain factors which affect the rate of enzyme activity.
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Give one example each for therapeutic and diagnostic applications of enzymes.
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Part B
Describe the pentose phosphate pathway of carbohydrate metabolism and write the significance of it.
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What do you mean by biological oxidation and oxidative phosphorylation? Describe in detail how the oxidation of a substrate take place through the respiratory chain in mitochondria mentioning the possible sites of ATP formation with reasons.
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Describe briefly the chemistry of cholesterol and its physiological importance. What is the normal blood cholesterol level?
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Give an account of the metabolism of fat with particular reference to beta oxidation. Describe the Catabolism of heme.
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Discuss the biosynthesis of purines and pyrimidines.
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Discuss the biological importance of nucleic acids
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Give the major steps involved in the messenger RNA transcription.
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Mention significances of ATP and cyclic AMP.
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Classify energy rich compounds. Write the functions and biological significance of cyclic AMP.
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Write the IUB classification of enzymes, citing suitable reaction under each class.
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Define and enlist the properties of enzymes. Add a note on their nomenclature.
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