Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy II Year MEDICINAL CHEMISTRY-I Previous Question Paper (May - 2019 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
Part A
Define pro drug with examples.
Answer
A prodrug is a pharmacologically inactive derivative of a drug molecule that requires chemical or enzymatic transformation within the body to release the active drug. Examples include levodopa (converted to dopamine) and enalapril (converted to enalaprilat).
Discuss the role of hydrogen bonding in drug action.
Answer
Hydrogen bonding is a crucial non-covalent interaction that facilitates the binding of a drug to its biological target (receptor or enzyme). It contributes to the specificity and affinity of the drug-receptor complex by stabilizing the interaction through electrostatic attraction between a hydrogen atom covalently bonded to an electronegative atom and another electronegative atom with a lone pair of electrons.
Write any two structures of beta adenergic blockers.
Answer
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Outline the catabolism of catecholamines.
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Classify cholinergic drugs.
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Give a short notes on neuro muscular blockers.
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Classify sedatives and hypnotics with examples.
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Write in detail about mechanism of action of anticonvulsants.
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Classify general anaesthetics with examples.
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Outline the synthesis of Methadone.
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Part B
Explain in detail about Phase II metabolic reactions with examples.
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Explain in detail about optical isomerism in drug action.
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Explain in detail about SAR of sympathomimetics.
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Write the synthesis of Salbutamol.
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Give the structures and uses of Tolazoline, Esmolol and Ephedrine.
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Classify cholinergic receptors and their bio distribution.
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Write the synthesis of Dicyclomine hydrochloride.
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Explain in detail about the Biosynthesis and catabolism of cholinergic receptors.
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Write in detail about SAR of Benzodiazepines.
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Write the synthesis of Chlorpromazine and Barbital.
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Write in detail about inhalation anesthetics.
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Classify synthetic morphine analogues.
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Explain in detail about morphine analogues as antitussives.
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