JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy II PHYSICAL PHARMACEUTICS-II Previous Question Paper (March - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Define zero order reaction.
Answer
A zero order reaction is a reaction in which the rate of degradation is independent of the concentration of the reactant. The rate equation is expressed as:
List out various physical and chemical factors influencing the chemical degradation of pharmaceutical products.
Answer
Physical factors include temperature, light (photolysis), moisture (hydrolysis), and humidity. Chemical factors include pH of the medium, presence of oxygen (oxidation), ionic strength, and the presence of catalysts or impurities.
Write about Thixotropy.
Answer
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Explain about the intrinsic factors influencing the viscosity of the fluid.
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Explain about settling in suspensions.
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Write about preservation of emulsions.
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Write about surface active agents.
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Define interfacial tension.
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Write about peptization.
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Classify the colloids.
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Part B
Explain about the Arrhenius equation to calculate degradation of drugs upon exposure to temperatures.
Answer
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Write about chemical decomposition by oxidation of medicinal agents and the methods to protect against oxidation.
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Explain about Brookfield viscometer and the viscosity measurement.
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Write the working principle of cup and bob viscometer with a labeled diagram.
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Define emulsions and explain the theories of emulsification.
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Explain the formulation details of suspensions.
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Explain about interfacial properties of suspended particles.
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List out the different methods of determination of surface and interfacial tension and write in detail about capillary rise method.
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Write about the spreading coefficient.
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Write about adsorption at liquid interfaces.
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Discuss the optical properties of colloids.
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Write the pharmaceutical application of colloids with examples.
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Write about instability of lyophobic colloids.
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