JNTU
JNTU B.Pharmacy III INDUSTRIAL PHARMACY-I Previous Question Paper (January/February - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Write the mechanism and problems associated with hydrolysis.
Answer
Hydrolysis is the chemical degradation of a drug molecule involving the cleavage of bonds by water. The mechanism typically involves nucleophilic attack by water or hydroxyl ions on electrophilic centers such as esters, amides, or lactams. Problems associated with hydrolysis include loss of potency, formation of toxic degradation products, and reduced shelf-life of pharmaceutical formulations.
Write BCS classification of drug.
Answer
The Biopharmaceutics Classification System (BCS) classifies drugs based on solubility and permeability:
- Class I: High Solubility, High Permeability
- Class II: Low Solubility, High Permeability
- Class III: High Solubility, Low Permeability
- Class IV: Low Solubility, Low Permeability
Define suspensions and emulsions.
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Write brief note on preservatives with two examples.
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Define base absorption and minimum/gram factor.
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Explain the weight variation test for capsules.
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Write the advantages of parenterals.
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What is meant by lyophillization and how it can be done?
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Write note on propellants.
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Write the official requirements for containers.
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Part B
Write the physical properties which required for preformulation study.
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What are the different preformulation considerations required for parenteral dosage forms.
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Write different methods of coating and explain film coating.
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Write the formulation and evaluation of solutions.
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Write preparation, storage and stability testing of soft gelatin capsules.
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Write mechanism and working of fluidized bed coater.
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Write the filling and sealing of ampoules and vials.
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Write the formulation aspects of eye drops, eye ointments and eye lotions.
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Write quality control and stability studies of aerosols.
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Write the preparation of lipsticks, cold cream and vanishing cream.
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