JNTU
JNTU B.Pharmacy III MEDICINAL CHEMISTRY-I Previous Question Paper (July - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Explain the Bioisosterism in related to biological action.
Answer
Bioisosterism refers to the substitution of an atom or group of atoms with another possessing similar physical or chemical properties, which produces broadly similar biological activities. It is used to optimize lead compounds by improving potency, reducing toxicity, or modifying pharmacokinetic properties.
Illustrate the phase-I drug metabolic reactions.
Answer
Phase-I reactions involve the introduction or unmasking of polar functional groups (-OH, -NH2, -SH, -COOH) to make the drug more hydrophilic. The primary reactions include:
- Oxidation: Catalyzed by Cytochrome P450 enzymes (e.g., hydroxylation, N-dealkylation).
- Reduction: Conversion of aldehydes/ketones to alcohols or nitro groups to amines.
- Hydrolysis: Cleavage of esters or amides by esterases or amidases.
Explain the catabolism of catecholamines.
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List the direct acting sympathomimetic agents.
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Write the structure and uses of Edrophonium chloride.
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Give a note on cholinesterase reactivator.
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Classify and differentiate hypnotics and sedatives.
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Give a note on alcohol and carbamate derivatives on CNS.
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Write the MOA and uses of Narcotic antagonist.
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Write the structure and MOA of mefenemic acid.
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Part B
Explain the following physico-chemical properties in relation to biological activity: a) Solubility b) Bioisosterism c) Chelation.
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Define and classify drug metabolism? Write the principles and reactions of phase-I metabolism.
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Outline the synthesis and mechanism of action of Tolazoline.
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Write the SAR of sympatholytic agents.
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What are the α adrenergic blockers? Write the mechanism and their uses.
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Write the SAR of β blockers.
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Describe the catabolism of Acetylcholine.
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Classify cholinergic blocking agents? Write the structure and uses of any two drugs.
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Write the synthesis and uses of Dicyclomine hydrochloride.
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Write the structure and uses of: i) Carbachole ii) Pralidoxime iii) Procyclidine.
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Classify Benzodiazepines? Write the SAR and mechanism of action.
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Write the synthesis and uses of Chlorpromazine hydrochloride.
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Give a brief note on oxazolidine diones.
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Write the classification, SAR and MOA of anticonvulsants.
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What are ultra short acting barbiturates? Write the structures and uses.
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Outline the synthesis and MOA of Ketamine.
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Classify Non steroidal Anti inflammatory agent? Write the synthesis of mefenamic acid.
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Write the structure and uses of the following: i) Pentazocine ii) Zomepriac iii) Acetaminophen.
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