JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy III SCREENING METHODS IN PHARMACOLOGY Previous Question Paper (February - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
Brief about the maintenance of laboratory animals as per CPCSEA guidelines?
Answer
CPCSEA guidelines mandate that laboratory animals must be housed in well-ventilated, temperature-controlled environments with appropriate light-dark cycles, sanitation, and ad libitum access to clean water and species-specific feed. Proper record-keeping, health monitoring by veterinarians, and adherence to the 3Rs (Replacement, Reduction, Refinement) are strictly required.
Application of transgenic animals.
Answer
Transgenic animals are used to study gene function, model human genetic diseases, test the efficacy of gene therapies, and produce therapeutic proteins. They serve as essential tools for understanding disease pathogenesis and evaluating the safety and efficacy of novel pharmacological interventions.
Write the full form of IAEC and OECD.
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What are the objectives of OECD guidelines?
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What different method used for screening anti-epileptic activity.
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Discuss the MES induced convulsion method?
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Enlist different methods for screening of type-2 Anti-diabetic activity.
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Explain one screening method for anti-asthmatic activity.
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Explain one method to screen antipyretic activity.
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Explain one screening method for anti-inflammatory activity.
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PART - B
Explain the handling and breeding techniques for laboratory mouse.
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Discuss in detail on alternatives to animal experiments.
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Write short notes on the following:
Transportation of laboratory animals
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Methods of euthanasia.
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Explain the teratogenicity screening.
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Elaborate the OECD guidelines for determining LD50.
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Explain the OECD-407 guidelines for determination of repeated dose toxicity in rodents.
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Explain the OECD guidelines for chronic toxicity studies.
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Describe in detail screening methods for sedatives and hypnotics.
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Enumerate methods to evaluate antidepressant activity of an agent. Discuss two in vivo methods.
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Discuss the methods to screen antipsychotic activity. Discuss two in-vivo methods.
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The commonly used methods to screen an agent for skeletal muscle relaxants agents. Discuss two in-vivo methods.
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Describe any two screening methods for anti-ulcer activity.
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Enlist methods to evaluate anti-diabetic activity of an agent. Discuss two in vivo method.
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Note on different screening models for Antihypertensive? Explain two kidney one clip hypertension method?
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Explain any one screening method for anti-arrhythmic agents.
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Explain one screening method for antipyretic activity.
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Discuss evaluation techniques for analgesic agents.
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Describe process of inflammation and screening methods for anti-inflammatory agents.
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Evaluation of in-vitro anti-inflammatory screening methods.
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