JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy IV BIOPHARMACEUTICS AND PHARMACOKINETICS Previous Question Paper (July - 2023 - R17)
Note: i) Question paper contains two parts, Part A, Part B. ii) Part A is compulsory which carries 25 marks. Answer all questions in Part A. iii) In Part B answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Define the term biopharmaceutics.
Answer
Biopharmaceutics is the study of the interrelationship between the physicochemical properties of a drug, the dosage form in which the drug is given, and the route of administration, on the rate and extent of systemic drug absorption.
Enlist the barriers in GI absorption.
Answer
- Gastrointestinal mucosal membrane (epithelial cell barrier)
- Unstirred water layer
- Mucus layer
- Tight junctions between epithelial cells
- Presystemic metabolism (gut wall and liver)
What is Drug distribution?
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Enlist the important proteins to which drug binding occur.
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Define drug metabolism.
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Enlist the preliminary routes of drug excretion.
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Define the term bioequivalence.
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What is absolute bioavailability and relative bioavailability?
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What is a ‘compartment’? Give examples.
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Discuss the concept of compartment modelling and its significance.
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Part B
Describe the formulation factors that affects drug absorption.
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Discuss the intracellular drug transport mechanism.
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Describe different mechanisms of gastrointestinal absorption.
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Enlist the important factors that influence drug absorption.
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Explain any two methods to estimate Tmax.
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Write about the significance of protein binding.
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Explain any four physicochemical factors influencing protein binding.
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Discuss the interaction between the drug and proteins.
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Explain the Phase-I biotransformation with examples.
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Differentiate between enzyme induction and enzyme inhibition.
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Describe in brief about organ clearance.
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Discuss about drugs excreted through lungs and skin.
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Describe the bioavailability testing procedure as per CDCSO.
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Explain any two methods for measuring bioavailability.
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Discuss different types of bioequivalence studies.
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Describe the study design for bioequivalence studies.
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Describe about one compartment open model for extravascular administration with an illustration and equation.
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Explain the calculation of pharmacokinetic parameters.
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Write a note on non-compartment models. Why is it used?
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