JNTU
JNTU B.Pharmacy III Year MEDICINAL CHEMISTRY-II Previous Question Paper (January/February - 2023 - R17)
Note: i) Question paper consists of Part A, Part B.
ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions.
iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
What is receptor and their distribution in human body?
Answer
A receptor is a specialized protein molecule located on the cell surface or within the cell that binds to specific ligands (like neurotransmitters or hormones) to initiate a biological response. They are distributed throughout the human body, primarily in the central nervous system, autonomic nervous system, cardiac tissue, smooth muscles, and endocrine glands.
Give the uses and synthesis of cimetidine.
Answer
Cimetidine is an H2-receptor antagonist used to treat peptic ulcers and gastroesophageal reflux disease (GERD). It is synthesized by the reaction of 4-hydroxymethylimidazole with cysteamine hydrochloride, followed by reaction with N-cyano-N'-methyl-S-methylisothiourea.
Give the uses and mechanism of action of nitroglycerin.
Answer
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What is diuretics? Outline the synthesis of chlorthiazide.
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What is hyper lipidemia? Mention the drugs used in the therapy.
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Give the uses and Outline the synthesis of disopyramide phosphate.
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Define is thyroid and antithyroid drugs with their example.
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Discuss in brief stereochemistry of steroids.
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Write down preparation of insulin.
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Give the SAR of sulphonyl urea.
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Part B
Explain the mechanism of action and SAR of H2- antagonists.
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Give the synthesis of mecaptopurine and methotrexate.
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Write a note on Alkylating agents.
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Identify Gastric Proton pump inhibitors? Classify them with examples.
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Give the mechanism of action of action and synthesis of isosorbide dinitrite.
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Write a note on loop diuretics.
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Write a note on Antihypertensive agents.
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Give the mechanism of action and uses of amlodipine.
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Classify coagulant and anti-coagulant drugs with example.
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Define and classify antihyperlipidemic drugs with examples.
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Outline the synthesis and mechanism of action of warfarin.
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What are anti-arrthythmatic agents? Classify with examples.
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Elaborate the physiological functions and uses of sex hormones.
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Write note on corticosteroids.
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Give the mechanism of action and uses of sildenafil and tadalafil.
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Give a brief note on oral contraceptives.
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Explain glucosidase inhibitors with mechanism of action.
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Give the mechanism of action and synthesis of butamben procaine.
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Explain the mechanism of action and uses of lidocaine/anilide derivatives drugs.
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Classify antidiabetic agents with examples.
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