JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy IV NOVEL DRUG DELIVERY SYSTEMS Previous Question Paper (January/February - 2023 - R17)
Part A is compulsory (25 Marks). In Part B, answer any one question from each unit (50 Marks). Each question in Part B carries 10 marks.
Part A
What are controlled drug delivery systems? Give examples.
Answer
Controlled drug delivery systems are formulations that release the active pharmaceutical ingredient at a predetermined rate, either continuously or in a pulsed manner, to maintain therapeutic drug levels in the blood for an extended period. Examples include osmotic pumps and transdermal patches.
Define and classify polymers.
Answer
Polymers are high molecular weight macromolecules composed of repeating structural units called monomers. They are classified into: 1) Natural polymers (e.g., starch, cellulose), 2) Synthetic polymers (e.g., PEG, PLA), and 3) Semi-synthetic polymers (e.g., HPMC, carboxymethyl cellulose).
What is microencapsulation? Write its advantages.
Answer
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Define mucoadhesion. List mucoadhesive polymers.
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Define transdermal drug delivery systems. Name 2 marketed transdermal systems.
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What are Gastroretentive delivery systems? Classify them.
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Describe the concept of Nanotechnology.
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Why targeted drug delivery systems required?
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Write the advantages of ocular drug delivery systems.
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List the applications of Intra uterine devices.
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Part B
Classify controlled release dosage forms with examples.
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Write about important considerations for selection of drug candidate.
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Explain the diffusion-controlled systems with illustration.
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Differentiate between controlled release and sustained release dosage forms.
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Explain any two methods used for microencapsulation.
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Enlist the disadvantage of microcapsules.
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Discuss the mechanism of mucoadhesion.
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Explain the formulation of buccal patches with its applications.
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Describe the formulation of dry powder inhalers. Give example of marketed inhaler.
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Enlist the advantages of pulmonary route of drug delivery.
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Discuss the concept of inflatable gastroretentive systems and its significance.
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Why are gastroretentive systems formulated?
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Discuss the concept of targeted drug delivery.
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Write about the formulation of Niosomes.
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What are liposomes? Classify liposomes.
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Explain any two methods of preparing liposomes.
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Discuss the concept of ocular drug delivery system.
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Describe the formulation of ocular inserts.
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Write about intra ocular barriers and the methods to overcome the same.
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List the novel ocular dosage forms.
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